Pyrimidine Derivatives as Precursors for Small Nucleic Acid Delivery Materials

• Product: Pyrimidine, 2-Hydroxypyrimidine, 2-Hydroxypyrimidine Hydrochloride
• Client Background: A domestic research institution focused on siRNA delivery systems.
• Project Requirements:
  • Pyrimidine backbone with potential for post-modification (hydroxyl/amino sites).
  • Low endotoxin levels, colorless appearance, and high solubility suitable for aqueous systems.
• Wealsun’s Solution:
  • Implemented specialized purification processes for 2-hydroxypyrimidine and its hydrochloride salt to enhance solubility and color grade.
  • Provided dual-batch samples accompanied by comprehensive analytical reports (NMR, LC-MS, UV).
• Outcomes:
  • The client successfully utilized the materials in nucleic acid precursor construction and included Wealsun in subsequent synthesis projects.
  • Jointly initiated the design of targeted synthesis strategies for more complex pyrimidine-based linkers.