- Product: Pyrimidine, 2-Hydroxypyrimidine, 2-Hydroxypyrimidine Hydrochloride
- Client Background: A domestic research institution focused on siRNA delivery systems.
- Project Requirements:
- Pyrimidine backbone with potential for post-modification (hydroxyl/amino sites).
- Low endotoxin levels, colorless appearance, and high solubility suitable for aqueous systems.
- Wealsun’s Solution:
- Implemented specialized purification processes for 2-hydroxypyrimidine and its hydrochloride salt to enhance solubility and color grade.
- Provided dual-batch samples accompanied by comprehensive analytical reports (NMR, LC-MS, UV).
- Outcomes:
- The client successfully utilized the materials in nucleic acid precursor construction and included Wealsun in subsequent synthesis projects.
- Jointly initiated the design of targeted synthesis strategies for more complex pyrimidine-based linkers.
Pyrimidine Derivatives as Precursors for Small Nucleic Acid Delivery Materials
2-Hydroxypyrimidine
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FAQ
What are pharmaceutical chemicals used for?
Pharmaceutical chemicals are used primarlyin the development,formulation,and production ofmedications. Theyinclude active ingredient,excipients,intermediates, and
other substances that ensure the drug’s effectiveness, stabilitv, and safety.
Q: How do pharmaceutical chemicals differ from other chemical products?
A: Pharmaceutical chemicals are specifically designed and manufactured to meet stringent purity, safety, and quality standards required in drug production. They undergo rigorous testing and comply with global regulations, unlike general chemical products which may not meet such high standards.
Q: What is the role of APIs in drug production?
A: Active Pharmaceutical Ingredients (APIs) are the main components responsible for the therapeutic effects of a drug. They directly target the medical condition being treated, making them crucial in every medication.
Q: How are pharmaceutical intermediates utilized?
A: Pharmaceutical intermediates are precursor compounds used in the synthesis of APIs. They are essential steps in the multi-stage production process of complex pharmaceutical compounds.
Q: Why are excipients essential in drug formulation?
A: Excipients are inactive substances that enhance drug formulation by acting as carriers, stabilizers, or binders. They help in the proper delivery, absorption, and shelf life of the medication.