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2-Pyrazinylmethanol
2-Pyrazinylmethanol (CAS 6705-33-5) is a strategically functionalized pyrazine derivative engineered for heterocyclic diversification, linker development, and pharmaceutical intermediate synthesis. This molecule integrates an electron-deficient pyrazine core—a six-membered aromatic diazine ring with nitrogen atoms at para positions (1,4)—with a hydroxymethyl substituent at the C2 position. The primary alcohol terminus serves as a versatile handle for esterification, etherification, oxidation to aldehyde/acid, or conversion to halides for cross-coupling strategies. The pyrazine ring provides unique hydrogen-bonding acceptor capability and metabolic stability compared to pyridine analogs, while the 2-substitution pattern enables specific binding orientations in kinase active sites. This intermediate is particularly valuable for constructing fused heterocycles, ATP-mimetic scaffolds, and nitrogen-rich ligands where the pyrazinyl-methanol motif balances electron-deficient character with synthetic flexibility. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to functionalized diazine architectures with tunable reactivity.
Property
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Product Name
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2-Pyrazinylmethanol
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CAS Number
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6705-33-5
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Chinese Name
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2-吡嗪甲醇
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Synonyms
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Pyrazin-2-ylmethanol; 2-(Hydroxymethyl)pyrazine; Pyrazine-2-methanol; C₅H₆N₂O heterocycle (corrected)
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Chinese Synonyms
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吡嗪 -2-基甲醇; 2-(羟甲基) 吡嗪; 吡嗪甲醇; 2-位羟甲基吡嗪
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Molecular Formula
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C₅H₆N₂O
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Molecular Weight
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110.12 g/mol
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Purity
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≥ 98% (HPLC/GC area normalization)
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Product Category
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Pharmaceutical Intermediates / Pyrazine Derivatives / Hydroxyalkyl Heterocycles
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Appearance
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White to Off-white Crystalline Powder or Solid
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Melting Point
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~85-90°C (estimated, literature reference recommended)
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Storage Conditions
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Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong oxidizing agents to avoid alcohol oxidation or ring degradation.
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Shelf Life
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24 months under recommended storage conditions
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Packaging
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100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
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Applications
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Heterocyclic library construction, kinase inhibitor scaffold development, linker synthesis for drug conjugates, pyrazine-based ligand development, alcohol derivatization (esterification/oxidation/halogenation)
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Reactivity
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Suitable for esterification, etherification, oxidation to aldehyde/acid, conversion to halides (for cross-coupling), electrophilic aromatic substitution at C3/C5/C6, and pyrazine ring functionalization
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Special Note
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✅ Electron-Deficient Heterocyclic Alcohol—pyrazine core provides unique binding geometry vs. pyridine analogs. Primary alcohol enables versatile derivatization. Part of our pyrazine building block series.
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