5-Bromo-2-fluoropyrimidine

5-Bromo-2-methylpyrimidine (CAS 62802-38-4), also known as 2-Methyl-5-bromopyrimidine or Pyrimidine, 5-bromo-2-methyl-, is a high-purity brominated methylpyrimidine intermediate widely used in pharmaceutical synthesis, organic chemistry research, nucleoside chemistry, and fine chemical manufacturing. This compound features a bromine substituent at the 5-position and a methyl group at the 2-position of the pyrimidine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic aromatic substitution, and heterocyclic functionalization, it exhibits excellent reactivity in Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, and selective bromine displacement pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, antiviral drug synthesis, kinase inhibitor development, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing brominated methylpyrimidine scaffolds, nucleoside analog precursors, heterocyclic kinase inhibitor intermediates, and specialty chemical precursors. As a reliable heterocyclic intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.

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Product Name	5-Bromo-2-methylpyrimidine
CAS Number	62802-38-4
Chinese Name	5-溴-2-甲基嘧啶
Synonyms	2-Methyl-5-bromopyrimidine; Pyrimidine, 5-bromo-2-methyl-; 5-Bromo-2-methyl-1,3-diazine; C₅H₅BrN₂ heterocycle; MFCD00674349
Chinese Synonyms	2-甲基-5-溴嘧啶; 5-溴-2-甲基-1,3-二氮杂苯; 溴甲基嘧啶; 5-溴-2-甲基吡嗪; 5-溴-2-甲基嘧啶
Molecular Formula	C₅H₅BrN₂
Molecular Weight	173.01 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Heterocyclic Compounds / Bromomethylpyrimidines
Appearance	Off-white to Light Yellow Crystalline Powder or Solid
Melting Point	45-50°C (estimated)
Boiling Point	~230-235°C at 760 mmHg (estimated)
Density	~1.6 g/cm³ (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases. Store sealed at room temperature or 2-8°C for extended stability.
Shelf Life	24 months under recommended storage conditions
Packaging	100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, nucleoside synthesis, antiviral drug development, kinase inhibitor synthesis, heterocyclic chemistry, selective bromine displacement reactions, agrochemical intermediates, fine chemical production
Reactivity	Suitable for Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, nucleophilic aromatic substitution, electrophilic aromatic substitution, bromine-directed ortho-functionalization, and methyl group derivatization