4-Piperidineethanol hydrochloride

4-Piperidineethanol hydrochloride (CAS 90747-17-4) is the hydrochloride salt form of 4-(2-hydroxyethyl)piperidine, engineered for pharmaceutical intermediate synthesis, ligand development, and heterocyclic construction. This molecule integrates a saturated piperidine core—with the secondary amine converted to a stable hydrochloride salt—and a 2-hydroxyethyl side chain at the C4 position. The hydrochloride salt form offers enhanced stability, improved crystallinity, better water solubility, and easier handling compared to the free base (CAS 622-26-4), making it particularly suitable for large-scale synthesis and long-term storage. The secondary amine hydrochloride can be readily liberated under basic conditions for alkylation, acylation, or reductive amination, while the primary alcohol terminus enables esterification, etherification, oxidation, or conversion to halides. This intermediate is particularly valuable for constructing CNS-active pharmaceuticals, opioid receptor modulators, and piperidine-based ligands where the salt form provides operational advantages during multi-step synthesis. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to stable, crystalline piperidine building blocks with defined protonation states.

Property

Product Name	4-Piperidineethanol hydrochloride
CAS Number	90747-17-4
Chinese Name	4-哌啶乙醇盐酸盐
Synonyms	2-(Piperidin-4-yl)ethanol hydrochloride; 4-(2-Hydroxyethyl)piperidine hydrochloride; Piperidine-4-ethanol HCl salt; C₇H₁₆ClNO hydrochloride
Chinese Synonyms	2-(哌啶-4-基) 乙醇盐酸盐; 4-(2-羟乙基) 哌啶盐酸盐; 哌啶-4-乙醇 HCl 盐; 羟乙基哌啶盐酸盐
Molecular Formula	C₇H₁₆ClNO
Molecular Weight	165.66 g/mol
Purity	≥ 98% (HPLC area normalization)
Product Category	Pharmaceutical Intermediates / Piperidine Derivatives / Amine Hydrochloride Salts
Appearance	White to Off-white Crystalline Powder
Melting Point	~152°C (decomposition, literature reference recommended)
pH (1% aq.)	~4.0-5.5 (acidic due to HCl salt)
Solubility	Highly soluble in water (>100 mg/mL); soluble in methanol/ethanol; insoluble in non-polar solvents
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong bases to avoid salt liberation and from strong oxidizing agents.
Shelf Life	24 months under recommended storage conditions
Packaging	100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications	CNS drug synthesis (opioid receptor modulators), piperidine-based ligand development, heterocyclic library construction, alcohol derivatization (esterification/etherification/oxidation), amine functionalization (after base liberation), salt screening for drug development
Reactivity	Suitable for base-mediated amine liberation, alcohol esterification/etherification, oxidation to aldehyde/acid, conversion to halides, reductive amination (after neutralization), and heterocyclic cyclization
Special Note	✅ Hydrochloride Salt Form—enhanced stability and crystallinity vs. free base (CAS 622-26-4). Water-soluble for aqueous reactions. Requires base treatment to liberate free amine for N-functionalization. Part of our piperidine building block series.