1-(2-broMo-6-Methoxy-phenyl)ethanone

1-(2-Bromo-6-methoxyphenyl)ethanone (CAS 380225-68-3) is a high-purity brominated methoxyacetophenone intermediate widely used in pharmaceutical synthesis, organic chemistry research, and fine chemical manufacturing. This compound features a bromine substituent at the ortho-position and a methoxy group at the adjacent position of the acetophenone structure, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic substitution, and heterocyclic synthesis, it exhibits excellent reactivity in Suzuki coupling, Heck reaction, Friedel-Crafts acylation, and cyclization reactions. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing ortho-substituted aromatic structures, benzofuran derivatives, chromone-based APIs, and agrochemical intermediates. As a specialized benzene derivative intermediate, it serves as an important precursor for constructing methoxy-protected phenolic scaffolds in drug discovery programs.

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Product Name	1-(2-Bromo-6-methoxyphenyl)ethanone
CAS Number	380225-68-3
Chinese Name	1-(2-溴-6-甲氧基苯基)乙酮
Synonyms	2′-Bromo-6′-methoxyacetophenone; Ethanone, 1-(2-bromo-6-methoxyphenyl)-; 2-Bromo-6-methoxyacetophenone; 1-(2-Bromo-6-methoxyphenyl)ethan-1-one; o-Bromo-m-anisyl methyl ketone; 2-Bromo-6-methoxyphenyl methyl ketone; 6-Methoxy-2-bromoacetophenone
Chinese Synonyms	2-溴-6-甲氧基苯乙酮; 1-(2-溴-6-甲氧基苯基)乙酮; 邻溴间甲氧基苯乙酮; 2-溴-6-甲氧基乙酰苯
Molecular Formula	C₉H₉BrO₂
Molecular Weight	229.07 g/mol
Purity	≥ 98% (HPLC/GC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Brominated Acetophenones
Appearance	White to Off-white Crystalline Powder or Light Yellow Solid
Melting Point	65-69°C (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from oxidation and strong bases.
Shelf Life	24 months under recommended storage conditions
Packaging	1kg/foil bag, 5kg/drum, 25kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, Suzuki/Heck cross-coupling, heterocyclic synthesis, benzofuran/chromone preparation, methoxy-protected aromatic drug development
Reactivity	Suitable for nucleophilic substitution, cross-coupling reactions, condensation reactions, etherification, esterification, and ortho-directed metalation
Special Note	✅ Specialized intermediate for ortho-substituted aromatic synthesis