5-Bromo-2-((tert-butoxycarbonyl)amino)benzoic acid

5-Bromo-2-((tert-butoxycarbonyl)amino)benzoic acid (CAS 306937-20-2), also known as N-Boc-5-bromoanthranilic acid, is a high-purity Boc-protected brominated anthranilic acid intermediate widely used in pharmaceutical synthesis, peptide chemistry, and organic chemistry research. This compound features a bromine substituent at the para-position and a tert-butoxycarbonyl (Boc) protected amino group at the ortho-position of the benzoic acid structure, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in peptide coupling reactions, cross-coupling chemistry, and functional group transformations, it exhibits excellent reactivity in Suzuki coupling, Heck reaction, amide bond formation, and Boc deprotection pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, peptide synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing brominated aromatic amino acid scaffolds, kinase inhibitor intermediates, and specialty chemical precursors. As a reliable benzene derivative intermediate, it serves as an important precursor for constructing Boc-protected aromatic amino systems in drug discovery and fine chemical development programs.

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Product Name	5-Bromo-2-((tert-butoxycarbonyl)amino)benzoic acid
CAS Number	306937-20-2
Chinese Name	N-Boc-5-溴邻氨基苯甲酸
Synonyms	N-Boc-5-bromoanthranilic acid; Boc-5-bromo-2-aminobenzoic acid; 5-Bromo-2-(Boc-amino)benzoic acid; 2-((tert-Butoxycarbonyl)amino)-5-bromobenzoic acid; Benzoic acid, 2-(((1,1-dimethylethoxy)carbonyl)amino)-5-bromo-; N-(tert-Butoxycarbonyl)-5-bromoanthranilic acid; Boc-NH-5-Br-anthranilic acid; 5-Br-2-BocNH-benzoic acid
Chinese Synonyms	5-溴-2-((叔丁氧羰基)氨基)苯甲酸; Boc-5-溴邻氨基苯甲酸; N-叔丁氧羰基-5-溴邻氨基苯甲酸; 5-溴-2-Boc氨基苯甲酸; 叔丁氧羰基-5-溴-2-氨基苯甲酸
Molecular Formula	C₁₂H₁₄BrNO₄
Molecular Weight	316.15 g/mol
Purity	≥ 98% (HPLC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Boc-Protected Amino Acids
Appearance	White to Off-white Crystalline Powder
Melting Point	180-185°C (decomposition, estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong acids and bases.
Shelf Life	24 months under recommended storage conditions
Packaging	1kg/foil bag, 5kg/drum, 25kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, peptide synthesis, API manufacturing, Suzuki/Heck cross-coupling, amide coupling reactions, Boc protection chemistry, kinase inhibitor synthesis, fine chemical production
Reactivity	Suitable for amide bond formation, Suzuki coupling, Heck reaction, Boc deprotection (acidic conditions), nucleophilic substitution, and bromine-directed ortho-functionalization