1-(2-Bromoethyl)-3-methoxybenzene

3-Methoxyphenethyl bromide (CAS 2146-61-4), also known as 1-(2-Bromoethyl)-3-methoxybenzene or m-Methoxyphenethyl bromide, is a high-purity methoxy-substituted phenethyl bromide intermediate widely used in pharmaceutical synthesis, organic chemistry research, and fine chemical manufacturing. This compound features a methoxy group at the meta-position and a bromoethyl side chain on the benzene ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in nucleophilic substitution reactions, cross-coupling chemistry, and functional group transformations, it exhibits excellent reactivity in Williamson ether synthesis, alkylation reactions, and Suzuki coupling pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing meta-methoxy aromatic structures, CNS-active drug intermediates, and agrochemical precursors. As a reliable benzene derivative intermediate, it serves as an important precursor for constructing methoxy-protected phenolic scaffolds in drug discovery and specialty chemical development programs.

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Product Name	3-Methoxyphenethyl bromide
CAS Number	2146-61-4
Chinese Name	3-甲氧基苯乙基溴
Synonyms	1-(2-Bromoethyl)-3-methoxybenzene; m-Methoxyphenethyl bromide; 2-(3-Methoxyphenyl)ethyl bromide; Benzene, 1-(2-bromoethyl)-3-methoxy-; 3-Methoxy-β-bromoethylbenzene; 1-(2-Bromoethyl)-3-methoxybenzene; 3-MeO-phenethyl bromide; β-Bromo-3-methoxyphenethyl; 2-(3-Methoxyphenyl)ethyl bromide; m-Anisyl ethyl bromide
Chinese Synonyms	间甲氧基苯乙基溴; 1-(2-溴乙基)-3-甲氧基苯; 2-(3-甲氧基苯基)溴乙烷; 3-甲氧基-β-溴乙苯; 间甲氧基-β-溴乙苯; 3-甲氧基苯基溴乙烷
Molecular Formula	C₉H₁₁BrO
Molecular Weight	215.09 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Methoxyphenethyl Halides
Appearance	Colorless to Light Yellow Liquid
Boiling Point	~240-245°C (estimated)
Density	~1.35 g/cm³ (estimated)
Refractive Index	n₂₀/D ~1.54 (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from oxidation and strong bases.
Shelf Life	24 months under recommended storage conditions
Packaging	25kg/drum, 50kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, nucleophilic substitution, cross-coupling reactions, CNS drug development, methoxy-aromatic compound synthesis, agrochemical intermediates, fine chemical production
Reactivity	Suitable for nucleophilic substitution, alkylation reactions, Williamson ether synthesis, Suzuki coupling, Heck reaction, and meta-methoxy-directed functionalization