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4-tert-Butylaniline
4-tert-Butylaniline (CAS 769-92-6), also known as p-tert-Butylaniline or 4-(tert-Butyl)aniline, is a high-purity tert-butyl-substituted aniline intermediate widely used in pharmaceutical synthesis, organic chemistry research, dye manufacturing, and fine chemical production. This compound features a tert-butyl group at the para-position of the aniline structure, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in electrophilic aromatic substitution, amide coupling, and functional group transformations, it exhibits excellent reactivity in diazotization, nucleophilic substitution, and cross-coupling pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, dye intermediate synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing para-tert-butyl aromatic amine scaffolds, agrochemical intermediates, and specialty chemical precursors. As a reliable benzene derivative intermediate, it serves as an important precursor for constructing sterically-hindered aromatic amine systems in drug discovery and fine chemical development programs.
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Product Name
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4-tert-Butylaniline
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CAS Number
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769-92-6
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Chinese Name
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4-叔丁基苯胺
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Synonyms
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p-tert-Butylaniline; 4-(tert-Butyl)aniline; Benzenamine, 4-(1,1-dimethylethyl)-; 4-tert-Butylphenylamine; p-(tert-Butyl)aniline; 1-Amino-4-tert-butylbenzene; 4-t-Butylaniline; p-tert-Butylphenylamine; 4-(1,1-Dimethylethyl)benzenamine
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Chinese Synonyms
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对叔丁基苯胺; 4-(叔丁基)苯胺; 对叔丁基苯基胺; 1-氨基-4-叔丁基苯; 4-叔丁基苯胺; 对特丁基苯胺
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Molecular Formula
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C₁₀H₁₅N
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Molecular Weight
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149.23 g/mol
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Purity
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≥ 98% (GC/HPLC)
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Product Category
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Pharmaceutical Intermediates / Benzene Derivatives / Aniline Derivatives
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Appearance
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Colorless to Light Yellow Liquid
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Boiling Point
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~230-235°C (estimated)
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Density
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~0.94 g/cm³ (estimated)
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Refractive Index
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n₂₀/D ~1.52 (estimated)
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Storage Conditions
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Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from oxidation and strong oxidizing agents.
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Shelf Life
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24 months under recommended storage conditions
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Packaging
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25kg/drum, 50kg/drum, or customized according to customer requirements
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Applications
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Pharmaceutical intermediates, organic synthesis, API manufacturing, dye intermediates, agrochemical intermediates, electrophilic aromatic substitution, amide coupling, fine chemical production
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Reactivity
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Suitable for diazotization, nucleophilic substitution, amide bond formation, electrophilic aromatic substitution, Suzuki coupling, and para-tert-butyl-directed functionalization
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