1,3,5-Tri-tert-butylbenzene

1,3,5-Tri-tert-butylbenzene (CAS 1460-02-2), also known as 1,3,5-Tris(1,1-dimethylethyl)benzene or Sym-tri-tert-butylbenzene, is a high-purity sterically-hindered aromatic hydrocarbon intermediate widely used in pharmaceutical synthesis, organic chemistry research, polymer chemistry, and fine chemical manufacturing. This compound features three tert-butyl groups symmetrically positioned at the 1,3,5-positions of the benzene ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in Friedel-Crafts alkylation, electrophilic aromatic substitution, and functional group transformations, it exhibits excellent reactivity in cross-coupling reactions, radical substitution, and benzylic functionalization pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, ligand synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing sterically-hindered aromatic scaffolds, polymer stabilizer precursors, organocatalyst ligands, agrochemical intermediates, and specialty chemical precursors. As a reliable benzene derivative intermediate, it serves as an important precursor for constructing bulky symmetric aromatic systems in drug discovery and fine chemical development programs.

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Product Name	1,3,5-Tri-tert-butylbenzene
CAS Number	1460-02-2
Chinese Name	1,3,5-三叔丁基苯
Synonyms	1,3,5-Tris(1,1-dimethylethyl)benzene; Sym-tri-tert-butylbenzene; Benzene, 1,3,5-tris(1,1-dimethylethyl)-; 1,3,5-Tri-t-butylbenzene; 1,3,5-Tris(tert-butyl)benzene; s-Tri-tert-butylbenzene; 1,3,5-(t-Bu)₃C₆H₃; 1,3,5-Tri-tert-butyl-benzene
Chinese Synonyms	1,3,5-三(1,1-二甲基乙基)苯; 对称三叔丁基苯; 1,3,5-三特丁基苯; 均三叔丁基苯; 1,3,5-三叔丁基苯
Molecular Formula	C₁₈H₃₀
Molecular Weight	246.43 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Sterically-Hindered Aromatics
Appearance	White to Off-white Crystalline Powder or Solid
Melting Point	70-74°C (literature)
Boiling Point	~280-285°C (estimated)
Density	~0.86 g/cm³ (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and acids.
Shelf Life	24 months under recommended storage conditions
Packaging	1kg/foil bag, 5kg/drum, 25kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, polymer stabilizers, ligand synthesis, Friedel-Crafts reactions, electrophilic aromatic substitution, agrochemical intermediates, fine chemical production, organocatalyst precursors
Reactivity	Suitable for electrophilic aromatic substitution, Suzuki coupling, Heck reaction, radical bromination, benzylic functionalization, and sterically-directed ortho-functionalization