1-Bromo-3,5-di-tert-butylbenzene

1-Bromo-3,5-di-tert-butylbenzene (CAS 22385-77-9), also known as 3,5-Di-tert-butylbromobenzene or 3,5-Bis(1,1-dimethylethyl)bromobenzene, is a high-purity sterically-hindered brominated aromatic intermediate widely used in pharmaceutical synthesis, organic chemistry research, polymer chemistry, and fine chemical manufacturing. This compound features two tert-butyl groups at the meta-positions and a bromine substituent on the benzene ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic substitution, and functional group transformations, it exhibits excellent reactivity in Suzuki coupling, Heck reaction, Grignard formation, and radical substitution pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, ligand synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing sterically-hindered aromatic scaffolds, polymer stabilizer precursors, agrochemical intermediates, and specialty chemical precursors. As a reliable benzene derivative intermediate, it serves as an important precursor for constructing bulky brominated aromatic systems in drug discovery and fine chemical development programs.

Property

Product Name	1-Bromo-3,5-di-tert-butylbenzene
CAS Number	22385-77-9
Chinese Name	3,5-二叔丁基溴苯
Synonyms	3,5-Bis(1,1-dimethylethyl)bromobenzene; Benzene, 1-bromo-3,5-bis(1,1-dimethylethyl)-; 3,5-Di-tert-butylbromobenzene; 1-Bromo-3,5-di-t-butylbenzene; 3,5-Bis(tert-butyl)bromobenzene; 5-Bromo-1,3-di-tert-butylbenzene; 3,5-(t-Bu)₂C₆H₃Br; 3,5-Di-tert-butyl-1-bromobenzene
Chinese Synonyms	3,5-双(1,1-二甲基乙基)溴苯; 3,5-二特丁基溴苯; 1-溴-3,5-二叔丁基苯; 5-溴-1,3-二叔丁基苯; 间二叔丁基溴苯
Molecular Formula	C₁₄H₂₁Br
Molecular Weight	269.22 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Sterically-Hindered Bromoarenes
Appearance	Colorless to Light Yellow Liquid or Low-Melting Solid
Boiling Point	~270-275°C (estimated)
Density	~1.15 g/cm³ (estimated)
Refractive Index	n₂₀/D ~1.52 (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases.
Shelf Life	24 months under recommended storage conditions
Packaging	25kg/drum, 50kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, Suzuki/Heck cross-coupling, Grignard reagent preparation, ligand synthesis, polymer stabilizers, agrochemical intermediates, fine chemical production
Reactivity	Suitable for Suzuki coupling, Heck reaction, Grignard formation, nucleophilic substitution, radical bromination, and sterically-directed ortho-functionalization