3,5-BIS(TRIFLUOROMETHYL)BENZENESULFONAMIDE

3,5-Bis(trifluoromethyl)benzenesulfonamide (CAS 39213-22-4) is a high-purity fluorinated benzene sulfonamide intermediate widely used in pharmaceutical synthesis, organic chemistry research, agrochemical development, and fine chemical manufacturing. This compound features two trifluoromethyl groups at the meta-positions and a sulfonamide functional group on the benzene ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in nucleophilic substitution, cross-coupling chemistry, and functional group transformations, it exhibits excellent reactivity in Suzuki coupling, amide coupling, and electrophilic aromatic substitution pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing fluorinated aromatic sulfonamide scaffolds, kinase inhibitor intermediates, agrochemical precursors, and specialty chemical precursors. As a reliable benzene derivative intermediate, it serves as an important precursor for constructing trifluoromethyl-functionalized aromatic systems in drug discovery and fine chemical development programs.

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Product Name	3,5-Bis(trifluoromethyl)benzenesulfonamide
CAS Number	39213-22-4
Chinese Name	3,5-二(三氟甲基)苯磺酰胺
Synonyms	3,5-Bis(trifluoromethyl)benzenesulphonamide; Benzenesulfonamide, 3,5-bis(trifluoromethyl)-; 3,5-Bis(trifluoromethyl)benzene-1-sulfonamide; 3,5-(CF₃)₂C₆H₃SO₂NH₂; BTFBSA; 3,5-Di(trifluoromethyl)benzenesulfonamide; m-Bis(trifluoromethyl)benzenesulfonamide
Chinese Synonyms	3,5-双(三氟甲基)苯磺酰胺; 3,5-二(三氟甲基)苯-1-磺酰胺; 间二(三氟甲基)苯磺酰胺; 3,5-二(三氟甲基)苯磺酰氨
Molecular Formula	C₉H₇F₆NO₂S
Molecular Weight	307.22 g/mol
Purity	≥ 98% (HPLC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Trifluoromethyl Sulfonamides
Appearance	White to Off-white Crystalline Powder
Melting Point	145-150°C (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong acids and bases.
Shelf Life	24 months under recommended storage conditions
Packaging	1kg/foil bag, 5kg/drum, 25kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, kinase inhibitor synthesis, agrochemical intermediates, fluorinated drug development, sulfonamide coupling reactions, fine chemical production
Reactivity	Suitable for nucleophilic substitution, Suzuki coupling, amide bond formation, electrophilic aromatic substitution, and trifluoromethyl-directed ortho-functionalization