(5-iodo-2-Methylphenyl)Methanol

(5-Iodo-2-methylphenyl)methanol (CAS 1260242-01-0), also known as 5-Iodo-2-methylbenzyl alcohol or (2-Methyl-5-iodophenyl)methanol, is a high-purity iodinated aromatic alcohol intermediate widely used in pharmaceutical synthesis, organic chemistry research, and fine chemical manufacturing. This compound features an iodine substituent at the para-position and a methyl group at the ortho-position of the benzyl alcohol structure, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic substitution, and functional group transformations, it exhibits excellent reactivity in Suzuki coupling, Sonogashira coupling, Heck reaction, and benzylic oxidation pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing iodinated aromatic scaffolds, kinase inhibitor intermediates, radiolabeling precursors, and specialty chemical precursors. As a reliable benzene derivative intermediate, it serves as an important precursor for constructing iodine-functionalized aromatic systems in drug discovery and fine chemical development programs.

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Product Name	(5-Iodo-2-methylphenyl)methanol
CAS Number	1260242-01-0
Chinese Name	(5-碘-2-甲基苯基)甲醇
Synonyms	5-Iodo-2-methylbenzyl alcohol; (2-Methyl-5-iodophenyl)methanol; Benzyl alcohol, 5-iodo-2-methyl-; 5-Iodo-o-tolylmethanol; 2-Methyl-5-iodobenzyl alcohol; 1-(Hydroxymethyl)-2-methyl-5-iodobenzene; 5-Iodo-2-methyl-α-hydroxytoluene; 2-Methyl-5-iodophenylmethanol
Chinese Synonyms	5-碘-2-甲基苄醇; 2-甲基-5-碘苯甲醇; 1-(羟甲基)-2-甲基-5-碘苯; 邻甲基间碘苯甲醇; 5-碘邻甲苯甲醇
Molecular Formula	C₈H₉IO
Molecular Weight	248.06 g/mol
Purity	≥ 98% (HPLC/GC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Iodinated Benzyl Alcohols
Appearance	White to Off-white Crystalline Powder or Light Yellow Solid
Melting Point	65-70°C (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from oxidation and strong oxidizing agents.
Shelf Life	24 months under recommended storage conditions
Packaging	1kg/foil bag, 5kg/drum, 25kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, Suzuki/Sonogashira/Heck cross-coupling, radiolabeling precursors, kinase inhibitor synthesis, benzylic functionalization, fine chemical production
Reactivity	Suitable for Suzuki coupling, Sonogashira coupling, Heck reaction, nucleophilic substitution, benzylic oxidation to aldehyde/acid, esterification, and iodine-directed ortho-functionalization