3-(4-Chlorophenyl)propan-1-ol

3-(2-Chlorophenyl)propanoic acid (CAS 6282-88-8), also known as o-Chlorohydrocinnamic acid or 2-Chlorobenzenepropanoic acid, is a high-purity chlorinated aromatic carboxylic acid intermediate widely used in pharmaceutical synthesis, organic chemistry research, and fine chemical manufacturing. This compound features a chlorine substituent at the ortho-position of the phenyl ring linked to a propanoic acid side chain, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in esterification, amide coupling, and functional group transformations, it exhibits excellent reactivity in Friedel-Crafts acylation, cross-coupling reactions, and derivatization pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing ortho-chlorophenyl scaffolds, anti-inflammatory drug intermediates, analgesic precursors, and specialty chemical precursors. As a reliable benzene derivative intermediate from our product line, it serves as an important precursor for constructing functionalized aromatic carboxylic acid systems in drug discovery and fine chemical development programs.

Property

Product Name	3-(2-Chlorophenyl)propanoic acid
CAS Number	6282-88-8
Chinese Name	3-(2-氯苯基)丙酸
Synonyms	o-Chlorohydrocinnamic acid; 2-Chlorobenzenepropanoic acid; Benzenepropanoic acid, 2-chloro-; 2′-Chlorohydrocinnamic acid; 3-(o-Chlorophenyl)propionic acid; 2-Chlorophenylpropionic acid; ClC₆H₄CH₂CH₂CO₂H; ortho-Chlorohydrocinnamic acid
Chinese Synonyms	邻氯氢化肉桂酸; 3-(邻氯苯基)丙酸; 2-氯苯丙酸; 邻氯苯基丙酸; 2-氯苯基丙酸; 邻氯苯基丙酸
Molecular Formula	C₉H₉ClO₂
Molecular Weight	184.62 g/mol
Purity	≥ 98% (HPLC/GC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Chlorophenyl Carboxylic Acids
Appearance	White to Off-white Crystalline Powder
Melting Point	75-80°C (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases.
Shelf Life	24 months under recommended storage conditions
Packaging	1kg/foil bag, 5kg/drum, 25kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, anti-inflammatory drug synthesis, analgesic precursors, esterification reactions, amide coupling, agrochemical intermediates, fine chemical production
Reactivity	Suitable for esterification, amide bond formation, Friedel-Crafts reactions, Suzuki coupling, nucleophilic substitution, and ortho-chloro-directed functionalization