2-Hydroxypyrimidine, HCl

2-Hydroxypyrimidine hydrochloride (CAS 38353-09-2), also known as Pyrimidin-2-ol hydrochloride or 2(1H)-Pyrimidinone hydrochloride, is a high-purity hydroxypyrimidine salt intermediate widely used in pharmaceutical synthesis, organic chemistry research, nucleoside chemistry, and fine chemical manufacturing. This compound features a hydroxyl/keto tautomeric group at the 2-position of the pyrimidine ring in its hydrochloride salt form, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in heterocyclic synthesis, nucleophilic substitution, and functional group transformations, it exhibits excellent reactivity in halogenation, amination, cross-coupling reactions, and salt formation pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, antiviral drug synthesis, Tipiracil intermediate production, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing hydroxypyrimidine scaffolds, nucleoside analog precursors, heterocyclic kinase inhibitor intermediates, and specialty chemical precursors. As a reliable heterocyclic intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.

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Product Name	2-Hydroxypyrimidine hydrochloride
CAS Number	38353-09-2
Chinese Name	2-羟基嘧啶盐酸盐
Synonyms	Pyrimidin-2-ol hydrochloride; 2(1H)-Pyrimidinone hydrochloride; 2-Pyrimidinol hydrochloride; Pyrimidine, 2-hydroxy-, hydrochloride; C₄H₄N₂O·HCl; MFCD00012781
Chinese Synonyms	嘧啶-2-醇盐酸盐; 2(1H)-嘧啶酮盐酸盐; 2-羟基嘧啶盐酸盐; 2-吡啶醇盐酸盐; 羟基嘧啶盐酸盐
Molecular Formula	C₄H₅ClN₂O
Molecular Weight	132.55 g/mol
Purity	≥ 98% (HPLC/Titration)
Product Category	Pharmaceutical Intermediates / Heterocyclic Compounds / Hydroxypyrimidine Salts
Appearance	White to Off-white Crystalline Powder or Solid
Melting Point	200-205°C (decomposition, literature)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases. Store sealed at 2-8°C for extended stability.
Shelf Life	24 months under recommended storage conditions
Packaging	100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, nucleoside synthesis, antiviral drug development, Tipiracil synthesis, heterocyclic chemistry, salt formation reactions, agrochemical intermediates, fine chemical production
Reactivity	Suitable for halogenation at C5/C6, nucleophilic substitution, amination, cross-coupling reactions, electrophilic aromatic substitution, and hydroxyl/keto group derivatization