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2-Bromopyrimidine
2-Bromopyrimidine (CAS 4595-60-2), also known as 2-Bromo-1,3-diazine or Pyrimidine, 2-bromo-, is a high-purity brominated heterocyclic intermediate widely used in pharmaceutical synthesis, organic chemistry research, nucleoside chemistry, and fine chemical manufacturing. This compound features a bromine substituent at the 2-position of the pyrimidine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic aromatic substitution, and heterocyclic functionalization, it exhibits excellent reactivity in Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, and selective bromine displacement pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, antiviral drug synthesis, kinase inhibitor development, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing bromopyrimidine scaffolds, nucleoside analog precursors, heterocyclic kinase inhibitor intermediates, and specialty chemical precursors. As a reliable heterocyclic intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.
Property
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Product Name
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2-Bromopyrimidine
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CAS Number
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4595-60-2
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Chinese Name
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2-溴嘧啶
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Synonyms
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2-Bromo-1,3-diazine; Pyrimidine, 2-bromo-; 2-Bromopyrimidine free base; C₄H₃BrN₂ heterocycle; MFCD00014601
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Chinese Synonyms
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2-溴-1,3-二氮杂苯; 溴代嘧啶; 2-溴吡嗪; 2-溴嘧啶碱; 溴嘧啶
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Molecular Formula
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C₄H₃BrN₂
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Molecular Weight
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158.98 g/mol
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Purity
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≥ 98% (GC/HPLC)
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Product Category
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Pharmaceutical Intermediates / Heterocyclic Compounds / Bromopyrimidines
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Appearance
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Pale Yellow to Light Yellow Crystalline Powder or Solid
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Melting Point
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55-57°C (literature)
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Boiling Point
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~180-185°C at 760 mmHg (estimated)
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Density
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~1.64 g/cm³ (estimated)
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Storage Conditions
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Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases. Store sealed at 2-8°C for extended stability.
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Shelf Life
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24 months under recommended storage conditions
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Packaging
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100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
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Applications
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Pharmaceutical intermediates, organic synthesis, API manufacturing, nucleoside synthesis, antiviral drug development, kinase inhibitor synthesis, heterocyclic chemistry, selective bromine displacement reactions, agrochemical intermediates, fine chemical production
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Reactivity
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Suitable for Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, nucleophilic aromatic substitution, electrophilic aromatic substitution, bromine-directed ortho-functionalization, and pyrimidine ring derivatization
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