2-Amino-5-bromopyridine

2-Amino-5-bromopyridine (CAS 1072-97-5), also known as 5-Bromopyridin-2-amine or 2-Pyridinamine, 5-bromo-, is a high-purity brominated aminopyridine intermediate widely used in pharmaceutical synthesis, organic chemistry research, and fine chemical manufacturing. This compound features a bromine substituent at the 5-position and an amino group at the 2-position of the pyridine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic aromatic substitution, and heterocyclic functionalization, it exhibits excellent reactivity in Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, and selective bromine displacement pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, kinase inhibitor synthesis (including Palbociclib intermediates), and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing bromoaminopyridine scaffolds, heterocyclic kinase inhibitor intermediates, and specialty chemical precursors. As a reliable pyridine derivative intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.

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Product Name	2-Amino-5-bromopyridine
CAS Number	1072-97-5
Chinese Name	2-氨基-5-溴吡啶
Synonyms	5-Bromopyridin-2-amine; 2-Pyridinamine, 5-bromo-; 5-Bromo-2-aminopyridine; 5-Bromo-2-pyridinamine; C₅H₅BrN₂ heterocycle; MFCD00006323
Chinese Synonyms	5-溴-2-氨基吡啶; 2-氨基-5-溴吡啶; 5-溴吡啶-2-胺; 溴氨基吡啶
Molecular Formula	C₅H₅BrN₂
Molecular Weight	173.01 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Pyridine Derivatives / Bromoaminopyridines
Appearance	Off-white to Light Yellow Crystalline Powder or Solid
Melting Point	85-90°C (literature)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and acids. Store sealed at 2-8°C for extended stability.
Shelf Life	24 months under recommended storage conditions
Packaging	100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, kinase inhibitor synthesis (Palbociclib intermediate), heterocyclic chemistry, selective bromine displacement reactions, agrochemical intermediates, fine chemical production
Reactivity	Suitable for Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, nucleophilic aromatic substitution, electrophilic aromatic substitution, bromine-directed ortho-functionalization, and amino group derivatization