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2,5-Dibromopyridine
2,5-Dibromopyridine (CAS 624-28-2), also known as Pyridine, 2,5-dibromo- or 2,5-Dibromo-1-azabenzene, is a high-purity dibrominated pyridine intermediate widely used in pharmaceutical synthesis, organic chemistry research, agrochemical development, and fine chemical manufacturing. This compound features bromine substituents at both the 2- and 5-positions of the pyridine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic aromatic substitution, and heterocyclic functionalization, it exhibits excellent reactivity in Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, Stille coupling, and selective bromine displacement pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, kinase inhibitor synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing dibromopyridine scaffolds, heterocyclic kinase inhibitor intermediates, agrochemical precursors, and specialty chemical precursors. As a reliable pyridine derivative intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.
Property
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Product Name
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2,5-Dibromopyridine
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CAS Number
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624-28-2
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Chinese Name
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2,5-二溴吡啶
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Synonyms
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Pyridine, 2,5-dibromo-; 2,5-Dibromo-1-azabenzene; 2,5-Dibromopyridine free base; C₅H₃Br₂N heterocycle; MFCD00006221
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Chinese Synonyms
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2,5-二溴-1-氮杂苯; 二溴吡啶; 2,5-二溴吡啶碱; 溴代吡啶
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Molecular Formula
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C₅H₃Br₂N
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Molecular Weight
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236.89 g/mol
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Purity
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≥ 98% (GC/HPLC)
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Product Category
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Pharmaceutical Intermediates / Pyridine Derivatives / Dibromopyridines
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Appearance
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White to Off-white to Light Brown Crystalline Powder or Solid
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Melting Point
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45-50°C (literature)
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Boiling Point
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~240-245°C at 760 mmHg (estimated)
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Density
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~2.1 g/cm³ (estimated)
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Storage Conditions
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Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases. Store sealed under inert atmosphere (nitrogen or argon) at 2-8°C for extended stability.
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Shelf Life
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24 months under recommended storage conditions
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Packaging
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100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
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Applications
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Pharmaceutical intermediates, organic synthesis, API manufacturing, kinase inhibitor synthesis, heterocyclic chemistry, selective bromine displacement reactions, agrochemical intermediates, fine chemical production
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Reactivity
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Suitable for Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, Stille coupling, nucleophilic aromatic substitution, electrophilic aromatic substitution, and bromine-directed ortho-functionalization
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