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3-picolylamine
3-(Aminomethyl)pyridine (CAS 3731-52-0), also known as 3-Picolylamine or Pyridin-3-ylmethanamine, is a high-purity aminomethyl-substituted pyridine intermediate widely used in pharmaceutical synthesis, organic chemistry research, agrochemical development, and fine chemical manufacturing. This compound features an aminomethyl group at the 3-position of the pyridine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in reductive amination, amide coupling, and heterocyclic functionalization, it exhibits excellent reactivity in nucleophilic substitution, condensation reactions, and pyridine ring derivatization pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, rodenticide intermediate synthesis (such as vacor precursors), and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing pyridylmethylamine scaffolds, heterocyclic kinase inhibitor intermediates, agrochemical precursors, and specialty chemical precursors. As a reliable pyridine derivative intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.
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Product Name
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3-(Aminomethyl)pyridine
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CAS Number
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3731-52-0
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Chinese Name
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3-氨甲基吡啶
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Synonyms
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3-Picolylamine; Pyridin-3-ylmethanamine; 3-Pyridinemethanamine; Picolamine; 3-AMPY; C₆H₈N₂ heterocycle; MFCD00006412
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Chinese Synonyms
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3-吡啶甲基胺; 3-氨甲基吡啶; 吡啶-3-基甲胺; 氨甲基吡啶; 3-皮考基胺
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Molecular Formula
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C₆H₈N₂
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Molecular Weight
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108.14 g/mol
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Purity
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≥ 98% (GC/HPLC)
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Product Category
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Pharmaceutical Intermediates / Pyridine Derivatives / Aminomethylpyridines
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Appearance
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Colorless to Light Yellow Liquid
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Melting Point
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-21°C (literature)
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Boiling Point
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73-74°C at 133.3 Pa (literature)
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Density
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1.062 g/cm³ at 20°C
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Refractive Index
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n₂₀/D ~1.551
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Flash Point
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100°C
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Storage Conditions
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Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen or argon). Protect from air oxidation. Store at 2-8°C for extended stability.
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Shelf Life
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24 months under recommended storage conditions
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Packaging
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100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
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Applications
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Pharmaceutical intermediates, organic synthesis, API manufacturing, rodenticide synthesis (vacor precursors), heterocyclic chemistry, reductive amination, amide coupling, agrochemical intermediates, fine chemical production
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Reactivity
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Suitable for reductive amination, amide bond formation, nucleophilic substitution, condensation with carbonyl compounds, and aminomethyl group derivatization
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