2-Methxy-3-nitropyridine

2-Methyl-3-nitropyridine (CAS 18699-87-1), also known as 3-Nitropicoline or 3-Nitro-2-picoline, is a high-purity nitro-methyl substituted pyridine intermediate widely used in pharmaceutical synthesis, organic chemistry research, agrochemical development, and fine chemical manufacturing. This compound features a methyl substituent at the 2-position and a nitro group at the 3-position of the pyridine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in reduction reactions, nucleophilic aromatic substitution, and heterocyclic functionalization, it exhibits excellent reactivity in catalytic hydrogenation (nitro to amino), cross-coupling reactions, and electrophilic aromatic substitution pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, kinase inhibitor synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing nitromethylpyridine scaffolds, heterocyclic kinase inhibitor intermediates, agrochemical precursors, and specialty chemical precursors. As a reliable pyridine derivative intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.

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Product Name	2-Methyl-3-nitropyridine
CAS Number	18699-87-1
Chinese Name	2-甲基-3-硝基吡啶
Synonyms	3-Nitropicoline; 3-Nitro-2-picoline; Pyridine, 2-methyl-3-nitro-; 2-Methyl-3-nitro-1-azabenzene; C₆H₆N₂O₂ heterocycle; MFCD04114137
Chinese Synonyms	3-硝基-2-甲基吡啶; 2-甲基-3-硝基-1-氮杂苯; 硝基甲基吡啶; 3-硝基邻甲基吡啶; 硝基皮考啉
Molecular Formula	C₆H₆N₂O₂
Molecular Weight	138.12 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Pyridine Derivatives / Nitromethylpyridines
Appearance	Yellow to Brown Crystalline Powder or Solid
Melting Point	24-28°C (literature)
Boiling Point	238°C (literature)
Density	1.228 g/mL at 25°C
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and reducing agents. Store sealed at 2-8°C for extended stability.
Shelf Life	24 months under recommended storage conditions
Packaging	100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, kinase inhibitor synthesis, heterocyclic chemistry, nitro reduction to amino, cross-coupling reactions, agrochemical intermediates, fine chemical production
Reactivity	Suitable for catalytic hydrogenation (nitro to amino), nucleophilic aromatic substitution, electrophilic aromatic substitution, cross-coupling reactions, and methyl/nitro group derivatization