3,5-Dibromo-2-pyridylamine

3,5-Dibromo-2-pyridylamine (CAS 35486-42-1), also known as 2-Amino-3,5-dibromopyridine, is a strategically functionalized halogenated heterocyclic scaffold engineered for cross-coupling reactions, pharmaceutical intermediate development, and ligand synthesis. This molecule integrates a pyridine core—a nitrogen-containing six-membered aromatic ring—with an amino substituent at the C2 position and two bromine atoms at the C3 and C5 positions. The C2-amino group provides nucleophilic reactivity for acylation, alkylation, diazotization, or heterocyclic fusion, while the dual bromine handles enable sequential or simultaneous Pd-catalyzed cross-coupling (Suzuki, Stille, Negishi, Sonogashira) to introduce diverse aryl, alkyl, or heteroaryl groups. This tri-functional architecture offers orthogonal reactivity patterns, making it particularly valuable for constructing kinase inhibitor cores, agrochemical actives, and asymmetric ligands where differentiated synthetic strategies are required. Compared to dibromopyridines without amino groups, this compound provides additional derivatization pathways through the nucleophilic nitrogen. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery and materials science programs requiring modular access to differentially functionalized pyridine architectures.