Other special intermediates preparation|Wealsun Biotech https://wealsunbio.com/product-category/other/ Sun, 01 Mar 2026 10:39:09 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://wealsunbio.com/wp-content/uploads/2025/06/20260211161228_5028_5-e1770797653670.png Other special intermediates preparation|Wealsun Biotech https://wealsunbio.com/product-category/other/ 32 32 Vanadyl acetylacetonate https://wealsunbio.com/product/vanadyl-acetylacetonate/ https://wealsunbio.com/product/vanadyl-acetylacetonate/#respond Sat, 24 Jan 2026 12:59:44 +0000 https://wealsunbio.com/?post_type=product&p=22351 Vanadyl acetylacetonate (CAS 3153-26-2), also known as bis(acetylacetonato)oxovanadium(IV) or VO(acac)₂, is a versatile vanadium(IV) coordination complex engineered for catalysis, materials science, and bioinorganic research applications. This molecule integrates a paramagnetic vanadyl core (VO²⁺) with two bidentate acetylacetonate (acac) ligands, creating a stable square-pyramidal geometry that balances reactivity with thermal stability. The labile oxo ligand and coordinatively unsaturated vanadium center enable efficient oxygen atom transfer, radical initiation, and Lewis acid catalysis, while the chelating acac ligands provide solubility in organic media and volatility suitable for vapor-phase deposition techniques. This intermediate is particularly valuable for constructing oxidation catalysts, chemical vapor deposition (CVD) precursors for vanadium oxide thin films, polymerization initiators, and model compounds for studying vanadium-dependent enzymes such as haloperoxidases and nitrogenases. Manufactured with purity ≥98% under controlled conditions, it supports research programs requiring reliable vanadium sources with well-defined coordination chemistry and tunable redox properties.

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Product Name
Vanadyl acetylacetonate
CAS Number
3153-26-2
Chinese Name
乙酰丙酮氧钒 (IV)
Synonyms
Bis(acetylacetonato)oxovanadium(IV); VO(acac)₂; Vanadyl(IV) acetylacetonate; Oxovanadium(IV) bis(acetylacetonate);
Chinese Synonyms
双 (乙酰丙酮) 氧钒; 氧钒 (IV) 乙酰丙酮; 乙酰丙酮钒酰; 
Molecular Formula
C₁₀H₁₄O₅V
Molecular Weight
265.16 g/mol
Purity
≥ 98% (elemental analysis/HPLC)
Product Category
Fine Chemicals / Coordination Compounds / Vanadium Precursors
Appearance
Blue to Blue-Green Crystalline Powder or Solid
Melting Point
~230-235°C (decomposition, literature reference recommended)
Magnetic Properties
Paramagnetic (d¹ configuration, S = 1/2); EPR-active
Solubility
Soluble in chloroform, dichloromethane, ethanol; sparingly soluble in water
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen or argon). Protect from strong oxidizing agents and bases to avoid oxidation to V(V) or ligand displacement.
Shelf Life
24 months under recommended storage conditions
Packaging
1g/bottle, 5g/bottle, 10g/bottle, 25g/bottle, or customized according to customer requirements (amber glass, sealed with PTFE liner)
Applications
Oxidation catalysis (alkene epoxidation, alcohol oxidation), CVD/ALD precursor for VO₂/V₂O₅ thin films, polymerization catalyst (olefin polymerization), bioinorganic model studies (vanadium enzymes), EPR spectroscopy standard, organic synthesis reagent
Reactivity
Suitable for oxygen atom transfer reactions, radical initiation, Lewis acid catalysis, ligand exchange, thermal decomposition to vanadium oxides, and redox cycling between V(IV)/V(V) states
Special Note
✅ Paramagnetic Vanadyl Complex—EPR-active d¹ system ideal for spectroscopic studies. Thermally Stable Volatile Precursor—suitable for vapor-phase deposition. Part of our transition metal coordination compound series.

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]]> https://wealsunbio.com/product/vanadyl-acetylacetonate/feed/ 0 tert-Butyl N-(3-aminopropyl)-N-methylcarbamate https://wealsunbio.com/product/tert-butyl-n-3-aminopropyl-n-methylcarbamate/ https://wealsunbio.com/product/tert-butyl-n-3-aminopropyl-n-methylcarbamate/#respond Sat, 24 Jan 2026 12:59:18 +0000 https://wealsunbio.com/?post_type=product&p=22350 tert-Butyl N-(3-aminopropyl)-N-methylcarbamate (CAS 150349-36-3) is a strategically protected aliphatic diamine engineered for peptide mimetic synthesis, linker development, and heterocyclic construction in medicinal chemistry. This molecule integrates a propylenediamine backbone—a flexible three-carbon spacer prevalent in bioactive molecules—with orthogonal functionalization: one nitrogen atom bears an acid-labile Boc (tert-butoxycarbonyl) protecting group and a methyl substituent, while the terminal nitrogen remains as a primary amine. This differential substitution pattern enables selective deprotection and sequential functionalization, allowing chemists to introduce distinct moieties at each nitrogen terminus with precise spacing control. Compared to its ethyl-linked analog (CAS 121492-06-6), the propyl spacer offers enhanced conformational flexibility and altered distance between pharmacophores, which is critical for optimizing binding affinity in receptor ligands. The methyl group modulates basicity and metabolic stability, while the Boc group ensures compatibility with base-sensitive reactions and facilitates purification. This intermediate is particularly valuable for constructing imidazolidines, piperazines, macrocyclic scaffolds, and antibody-drug conjugate (ADC) linkers where controlled nitrogen reactivity and chain length are critical. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to differentially protected aliphatic diamine architectures.

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Product Name
tert-Butyl N-(3-aminopropyl)-N-methylcarbamate
CAS Number
150349-36-3
Chinese Name
叔丁基 N-(3-氨基丙基)-N-甲基氨基甲酸酯
Synonyms
Boc-N-Methyl-1,3-diaminopropane; N-Boc-N’-methylpropylenediamine; C₉H₂₀N₂O₂ protected diamine; Boc-Me-Propyl-EDA
Chinese Synonyms
Boc-甲基 -1,3-二氨基丙烷; N-Boc-N’-甲基丙二胺; 叔丁基甲基氨基丙基氨基甲酸酯; 保护性二胺中间体
Molecular Formula
C₉H₂₀N₂O₂
Molecular Weight
188.27 g/mol
Purity
≥ 98% (GC/HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Protected Amines / Aliphatic Diamines
Appearance
Colorless to Pale Yellow Liquid
Boiling Point
~250-260°C at 760 mmHg (estimated)
Density
~0.96 g/cm³ (estimated)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong acids to avoid premature Boc deprotection.
Shelf Life
18-24 months under recommended storage conditions
Packaging
100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications
Peptide mimetic synthesis, heterocyclic construction (imidazolidines/piperazines), drug-linker conjugate development (ADC linkers), macrocyclic scaffold synthesis, sequential functionalization of diamines
Reactivity
Suitable for selective Boc deprotection (TFA/HCl), free amine acylation/alkylation, reductive amination, heterocyclic cyclization, and orthogonal protection strategies
Special Note
✅ Differentially Protected Diamine—enables sequential N-functionalization. Propyl spacer offers enhanced flexibility vs. ethyl analogs (CAS 121492-06-6). Acid-Sensitive Boc—avoid strong acids during storage. Part of our protected amine building block series.

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]]> https://wealsunbio.com/product/tert-butyl-n-3-aminopropyl-n-methylcarbamate/feed/ 0 6-Chloropyridazine-3-carboxylic acid https://wealsunbio.com/product/6-chloropyridazine-3-carboxylic-acid/ https://wealsunbio.com/product/6-chloropyridazine-3-carboxylic-acid/#respond Sat, 24 Jan 2026 12:58:52 +0000 https://wealsunbio.com/?post_type=product&p=22349 6-Chloropyridazine-3-carboxylic acid (CAS 5096-73-1) is a strategically functionalized pyridazine scaffold engineered for heterocyclic diversification in agrochemical and pharmaceutical development. This molecule integrates a pyridazine core—a six-membered diazine ring with two adjacent nitrogen atoms—with a chlorine substituent at the C6 position and a carboxylic acid group at the C3 position. The C6-chloro handle is highly activated for nucleophilic aromatic substitution (SNAr) due to the electron-withdrawing effects of both the adjacent ring nitrogens and the C3-carboxylic acid, enabling efficient displacement with amines, thiols, or alkoxides. The carboxylic acid moiety serves as a versatile synthetic handle for amide coupling, esterification, or decarboxylative cross-coupling strategies. This intermediate is particularly valuable for constructing pyridazinone herbicides, kinase inhibitor cores, and bioactive heterocycles where the electron-deficient diazine architecture enhances target binding affinity and metabolic stability. Compared to its nitrile (CAS 35857-89-7) or hydroxyl (CAS 19064-67-6) analogs, the carboxylic acid form offers direct access to amide libraries and salt formation for solubility enhancement. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery and agrochemical research programs requiring modular access to chlorinated carboxypyridazine architectures.

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Product Name
6-Chloropyridazine-3-carboxylic acid
CAS Number
5096-73-1
Chinese Name
6-氯哒嗪 -3-羧酸
Synonyms
6-Chloro-3-pyridazinecarboxylic acid; 6-Chloropyridazine-3-carboxylate; 6-Chloropyridazine-3-carboxylic acid
Chinese Synonyms
6-氯 -3-哒嗪羧酸; 6-氯哒嗪 -3-甲酸; 氯羧基哒嗪; 6-氯哒嗪羧酸
Molecular Formula
C₅H₃ClN₂O₂
Molecular Weight
158.54 g/mol
Purity
≥ 98% (HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Agrochemical Intermediates / Pyridazine Derivatives
Appearance
White to Off-white Crystalline Powder
Melting Point
~198-202°C (decomposition, literature reference recommended)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong bases to avoid hydrolysis of the C6-Cl bond or salt formation.
Shelf Life
24 months under recommended storage conditions
Packaging
100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications
Pyridazinone herbicide synthesis, kinase inhibitor scaffold development, heterocyclic library construction via SNAr at C6, amide coupling at C3-COOH, salt formation for solubility
Reactivity
Suitable for nucleophilic aromatic substitution (C6-Cl displacement), amide coupling (activation via EDC/HATU), esterification, decarboxylative coupling, and cyclization to fused rings
Special Note
✅ Dual-Functionality Scaffold—C3-COOH for coupling, C6-Cl for substitution. Electron-deficient ring enhances SNAr reactivity. Distinct from nitrile/hydroxyl analogs by direct amide access. Part of our diazine building block series.

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]]> https://wealsunbio.com/product/6-chloropyridazine-3-carboxylic-acid/feed/ 0 N-Boc-N-methylethylenediamine https://wealsunbio.com/product/n-boc-n-methylethylenediamine/ https://wealsunbio.com/product/n-boc-n-methylethylenediamine/#respond Sat, 24 Jan 2026 12:58:28 +0000 https://wealsunbio.com/?post_type=product&p=22348 N-Boc-N-methylethylenediamine (CAS 121492-06-6) is a strategically protected aliphatic diamine engineered for peptide mimetic synthesis, heterocyclic construction, and linker development in medicinal chemistry. This molecule integrates an ethylenediamine backbone—a flexible two-carbon spacer prevalent in bioactive molecules—with orthogonal functionalization: one nitrogen atom bears an acid-labile Boc (tert-butoxycarbonyl) protecting group, while the other carries a methyl substituent. This differential substitution pattern enables selective deprotection and sequential functionalization, allowing chemists to introduce distinct moieties at each nitrogen terminus. The methyl group provides metabolic stability and modulates basicity compared to unsubstituted ethylenediamine, while the Boc group ensures compatibility with base-sensitive reactions and facilitates purification. This intermediate is particularly valuable for constructing imidazolidines, piperazines, macrocyclic scaffolds, and drug-linker conjugates where controlled nitrogen reactivity is critical. Manufactured under controlled conditions, it supports drug discovery programs requiring modular access to differentially protected aliphatic diamine architectures.

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Product Name
N-Boc-N-methylethylenediamine
CAS Number
121492-06-6
Chinese Name
N-Boc-N-甲基乙二胺
Synonyms
tert-Butyl (2-aminoethyl)(methyl)carbamate; N-Boc-N’-methylethylenediamine; C₈H₁₈N₂O₂ protected diamine; Boc-Me-EDA
Chinese Synonyms
叔丁基 (2-氨基乙基)(甲基) 氨基甲酸酯; N-Boc-N’-甲基乙二胺; Boc-甲基乙二胺; 保护性二胺中间体
Molecular Formula
C₈H₁₈N₂O₂
Molecular Weight
174.24 g/mol 
Purity
≥ 98% (GC/HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Protected Amines / Aliphatic Diamines
Appearance
Colorless to Pale Yellow Liquid
Boiling Point
~240-250°C at 760 mmHg (estimated)
Density
~0.95 g/cm³ (estimated)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong acids to avoid premature Boc deprotection.
Shelf Life
18-24 months under recommended storage conditions
Packaging
100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications
Peptide mimetic synthesis, heterocyclic construction (imidazolidines/piperazines), drug-linker conjugate development, macrocyclic scaffold synthesis, sequential functionalization of diamines
Reactivity
Suitable for selective Boc deprotection (TFA/HCl), free amine acylation/alkylation, reductive amination, heterocyclic cyclization, and orthogonal protection strategies
Special Note
✅ Differentially Protected Diamine—enables sequential N-functionalization. Methyl group modulates basicity vs. unsubstituted analogs. Acid-Sensitive Boc—avoid strong acids during storage. Part of our protected amine building block series.

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]]> https://wealsunbio.com/product/n-boc-n-methylethylenediamine/feed/ 0 6-Chloropyridazine-3-carbonitrile https://wealsunbio.com/product/6-chloropyridazine-3-carbonitrile/ https://wealsunbio.com/product/6-chloropyridazine-3-carbonitrile/#respond Sat, 24 Jan 2026 12:58:07 +0000 https://wealsunbio.com/?post_type=product&p=22347 6-Chloropyridazine-3-carbonitrile (CAS 35857-89-7) is a strategically functionalized pyridazine scaffold engineered for heterocyclic diversification in agrochemical and pharmaceutical development. This molecule integrates a pyridazine core—a six-membered diazine ring with two adjacent nitrogen atoms—with a chlorine substituent at the C6 position and a carbonitrile group at the C3 position. The C6-chloro handle is highly activated for nucleophilic aromatic substitution (SNAr) due to the electron-withdrawing effects of both the adjacent ring nitrogens and the C3-nitrile group, enabling efficient displacement with amines, thiols, or alkoxides. The nitrile moiety serves as a versatile synthetic handle for hydrolysis to carboxylic acids, reduction to aminomethyl groups, or cyclization to form fused heterocyclic systems. This intermediate is particularly valuable for constructing pyridazinone herbicides, kinase inhibitor cores, and bioactive heterocycles where the electron-deficient diazine architecture enhances target binding affinity and metabolic stability. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery and agrochemical research programs requiring modular access to chlorinated cyanopyridazine architectures.

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Product Name
6-Chloropyridazine-3-carbonitrile
CAS Number
35857-89-7
Chinese Name
6-氯哒嗪 -3-甲腈
Synonyms
6-Chloro-3-cyanopyridazine; 6-Chloropyridazine-3-carbonitrile; C₅H₂ClN₃ heterocycle; Chlorocyano-pyridazine
Chinese Synonyms
6-氯 -3-氰基哒嗪; 6-氯哒嗪 -3-腈; 氯氰基哒嗪; 6-氯哒嗪甲腈
Molecular Formula
C₅H₂ClN₃
Molecular Weight
139.54 g/mol 
Purity
≥ 98% (HPLC/GC area normalization)
Product Category
Pharmaceutical Intermediates / Agrochemical Intermediates / Pyridazine Derivatives
Appearance
White to Off-white Crystalline Powder
Melting Point
~144-148°C (estimated, literature reference recommended)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong bases to avoid hydrolysis of the nitrile or displacement of the chloride.
Shelf Life
24 months under recommended storage conditions
Packaging
100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications
Pyridazinone herbicide synthesis, kinase inhibitor scaffold development, heterocyclic library construction via SNAr at C6, nitrile transformation (hydrolysis/reduction/cyclization)
Reactivity
Suitable for nucleophilic aromatic substitution (C6-Cl displacement), nitrile hydrolysis to acid, nitrile reduction to amine, cyclization to fused rings, and Pd-catalyzed cross-coupling
Special Note
✅ Dual-Electron-Withdrawing Scaffold—C3-CN activates C6-Cl for SNAr. Distinct from 6-chloropyridazin-3-ol (CAS 19064-67-6) by nitrile vs. hydroxyl functionality. Part of our diazine building block series.

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]]> https://wealsunbio.com/product/6-chloropyridazine-3-carbonitrile/feed/ 0 2-Naphthoxyacetic acid https://wealsunbio.com/product/2-naphthoxyacetic-acid/ https://wealsunbio.com/product/2-naphthoxyacetic-acid/#respond Sat, 24 Jan 2026 12:56:26 +0000 https://wealsunbio.com/?post_type=product&p=22343 2-Naphthoxyacetic acid (CAS 120-23-0) is a strategically functionalized naphthalene derivative engineered for plant growth regulation, agrochemical development, and organic synthesis applications. This molecule integrates a 2-naphthol core—a fused bicyclic aromatic system with extended π-conjugation—with an oxyacetic acid side chain at the C2 position, creating an auxin-like pharmacophore that mimics natural indole-3-acetic acid (IAA). The ether linkage between the naphthalene ring and acetic acid moiety provides enhanced metabolic stability compared to direct aryl-acetic acid analogs, while the carboxylic acid terminus enables salt formation, esterification, or amide coupling for formulation optimization. This intermediate is particularly valuable for constructing rooting promoters, fruit-setting agents, and parthenocarpy inducers in agricultural biotechnology, as well as serving as a versatile building block for pharmaceutical scaffold synthesis and fluorescent probe development. Manufactured with purity ≥98% under controlled conditions, it supports agrochemical research programs requiring reliable auxin-mimetic compounds with tunable lipophilicity and environmental persistence.

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Product Name
2-Naphthoxyacetic acid
CAS Number
120-23-0
Chinese Name
2-萘氧基乙酸
Synonyms
β-Naphthoxyacetic acid; 2-(2-Naphthyloxy)acetic acid; Naphthalen-2-yloxyacetic acid; C₁₂H₁₀O₃ aromatic acid
Chinese Synonyms
β-萘氧基乙酸; 2-(2-萘基氧基) 乙酸; 萘 -2-基氧基乙酸; 萘氧乙酸
Molecular Formula
C₁₂H₁₀O₃
Molecular Weight
202.21 g/mol
Purity
≥ 98% (HPLC area normalization)
Product Category
Agrochemical Intermediates / Plant Growth Regulators / Naphthalene Derivatives
Appearance
White to Off-white Crystalline Powder
Melting Point
154-157°C (literature)
pKa
~3.5-4.0 (carboxylic acid, estimated)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases to avoid decarboxylation or ether cleavage.
Shelf Life
24 months under recommended storage conditions
Packaging
100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications
Plant rooting promoter, fruit-setting agent, parthenocarpy inducer, agrochemical formulation development, auxin receptor research, pharmaceutical scaffold synthesis, fluorescent probe precursor
Reactivity
Suitable for esterification, amide coupling, salt formation with organic/inorganic bases, electrophilic aromatic substitution on naphthalene ring, and ether linkage stability studies
Special Note
✅ Auxin-Mimetic Scaffold—naphthalene core provides enhanced lipophilicity vs. indole analogs. Ether linkage offers metabolic stability. Part of our plant growth regulator series.

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]]> https://wealsunbio.com/product/2-naphthoxyacetic-acid/feed/ 0 S-Butyrylthiocholine iodide https://wealsunbio.com/product/s-butyrylthiocholine-iodide/ https://wealsunbio.com/product/s-butyrylthiocholine-iodide/#respond Sat, 24 Jan 2026 12:56:07 +0000 https://wealsunbio.com/?post_type=product&p=22342 S-Butyrylthiocholine iodide (CAS 1866-16-6) is a specialized chromogenic substrate engineered for quantitative measurement of butyrylcholinesterase (BChE, pseudocholinesterase) activity in biochemical research, clinical diagnostics, and toxicology screening. This molecule integrates a butyryl thioester moiety—a selective acyl donor for BChE over acetylcholinesterase (AChE)—with a thiocholine leaving group that enables sensitive colorimetric detection via Ellman's reagent (DTNB). Upon enzymatic hydrolysis by BChE, the released thiocholine rapidly reacts with 5,5'-dithiobis-(2-nitrobenzoic acid) to generate the yellow-colored 5-thio-2-nitrobenzoate anion (TNB⁻), measurable at 412 nm. This intermediate is particularly valuable for assessing liver function, monitoring organophosphate exposure, screening cholinesterase inhibitors for Alzheimer's disease research, and validating enzyme kinetics in drug discovery pipelines. Manufactured under controlled conditions, it supports research programs requiring reliable, specific substrates for pseudocholinesterase activity quantification.

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Product Name
S-Butyrylthiocholine iodide
CAS Number
1866-16-6
Chinese Name
S-丁酰硫代胆碱碘化物
Synonyms
Butyrylthiocholine iodide; BTCI; S-Butyrylthiocholine iodide salt; C₉H₂₀INOS quaternary ammonium compound
Chinese Synonyms
丁酰硫代胆碱碘盐; 碘化 S-丁酰硫代胆碱; BTCI 底物; 丁酰胆碱酯酶底物
Molecular Formula
C₉H₂₀INOS
Molecular Weight
317.23 g/mol 
Purity
≥ 98% (HPLC area normalization)
Product Category
Biochemical Reagents / Enzyme Substrates / Cholinesterase Assay Reagents
Appearance
White to Off-white Crystalline Powder
Melting Point
~140-145°C (decomposition, literature reference recommended)
Solubility
Highly soluble in water (>100 mg/mL); soluble in methanol; insoluble in non-polar solvents
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen) at -20°C. Protect from oxidizing agents to avoid thioester degradation.
Shelf Life
12-18 months under recommended storage conditions (monitor for hydrolysis)
Packaging
100mg/vial, 500mg/vial, 1g/bottle, or customized according to customer requirements (amber glass, sealed with PTFE liner)
Applications
Butyrylcholinesterase activity assay (Ellman’s method), liver function testing, organophosphate toxicity screening, cholinesterase inhibitor drug discovery, Alzheimer’s disease research, clinical diagnostic kit development
Reactivity
Suitable for enzymatic hydrolysis by BChE, thiocholine release quantification via DTNB reaction, kinetic parameter determination (Km, Vmax), and inhibitor IC₅₀ screening
Special Note
✅ BChE-Selective Substrate—butyryl thioester provides specificity over AChE. Hygroscopic & Light-Sensitive—store desiccated at -20°C in amber vials. Part of our enzyme assay reagent series.

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]]> https://wealsunbio.com/product/s-butyrylthiocholine-iodide/feed/ 0 6-Chloropyridazin-3-ol https://wealsunbio.com/product/6-chloropyridazin-3-ol/ https://wealsunbio.com/product/6-chloropyridazin-3-ol/#respond Sat, 24 Jan 2026 12:55:45 +0000 https://wealsunbio.com/?post_type=product&p=22341 6-Chloropyridazin-3-ol (CAS 19064-67-6) is a strategically functionalized pyridazine scaffold engineered for agrochemical and pharmaceutical intermediate synthesis. This molecule integrates a pyridazine core—a six-membered heterocycle with two adjacent nitrogen atoms—with a chlorine substituent at the C6 position and a hydroxyl group at the C3 position. The C6-chloro handle is activated by the adjacent ring nitrogens, enabling efficient nucleophilic aromatic substitution (SNAr) or Pd-catalyzed cross-coupling, while the 3-hydroxyl moiety exists in tautomeric equilibrium with the 3-one form (pyridazin-3-one), offering versatile alkylation or derivatization sites. This intermediate is particularly valuable for constructing pyridazinone herbicides, kinase inhibitor cores, and heterocyclic libraries where the adjacent nitrogen pattern provides unique hydrogen-bonding geometry and electronic properties compared to pyridine or pyrimidine analogs. Manufactured under controlled conditions, it supports drug discovery and agrochemical development programs requiring modular access to chlorinated diazine architectures.

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Product Name
6-Chloropyridazin-3-ol
CAS Number
19064-67-6
Chinese Name
6-氯哒嗪 -3-醇
Synonyms
6-Chloro-3-hydroxypyridazine; 6-Chloropyridazin-3(2H)-one; C₄H₃ClN₂O heterocycle; Chlorohydroxypyridazine
Chinese Synonyms
6-氯 -3-羟基哒嗪; 6-氯哒嗪 -3-酮; 氯羟基哒嗪; 6-氯 -3-氧代哒嗪
Molecular Formula
C₄H₃ClN₂O
Molecular Weight
130.53 g/mol
Purity
≥ 98% (HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Agrochemical Intermediates / Pyridazine Derivatives
Appearance
Off-white to Light Yellow Crystalline Powder
Melting Point
~230-235°C (decomposition, literature reference recommended)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong bases to avoid hydrolysis of the C6-Cl bond or ring degradation.
Shelf Life
24 months under recommended storage conditions
Packaging
100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications
Pyridazinone herbicide synthesis, kinase inhibitor scaffold development, heterocyclic library construction, nucleophilic substitution at C6, O-alkylation at C3
Reactivity
Suitable for nucleophilic aromatic substitution (C6-Cl displacement), O-alkylation/acylation (C3-OH), Pd-catalyzed cross-coupling, tautomerization control, and ring fusion reactions
Special Note
✅ Tautomeric Scaffold—exists as 3-ol/3-one equilibrium. C6-Cl is highly activated by adjacent nitrogens for substitution. Distinct from pyridine/pyrimidine by N-N adjacency. Part of our diazine building block series.

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]]> https://wealsunbio.com/product/6-chloropyridazin-3-ol/feed/ 0 (5-Bromothien-2-yl)methanol https://wealsunbio.com/product/5-bromothien-2-ylmethanol/ https://wealsunbio.com/product/5-bromothien-2-ylmethanol/#respond Sat, 24 Jan 2026 12:55:22 +0000 https://wealsunbio.com/?post_type=product&p=22340 (5-Bromothien-2-yl)methanol (CAS 79387-71-6) is a strategically functionalized thiophene derivative engineered for cross-coupling reactions and heterocyclic diversification in medicinal chemistry and materials science. This molecule integrates a 2,5-disubstituted thiophene core—a linear conjugated system prevalent in conductive polymers and pharmaceuticals—with a bromine atom at the C5 position and a hydroxymethyl group at the C2 position. The C5-bromo handle serves as a privileged site for Pd-catalyzed cross-coupling (Suzuki, Stille, Negishi), enabling efficient extension of the π-conjugated system, while the C2-hydroxymethyl moiety provides a versatile handle for oxidation to aldehyde/acid, esterification, or conversion to halides for further functionalization. The 2,5-substitution pattern offers distinct electronic properties compared to 2,3- or 3-substituted analogs, facilitating linear charge transport in organic electronics and specific binding orientations in biological targets. This intermediate is particularly valuable for constructing thiophene-based oligomers, kinase inhibitor scaffolds, and agrochemical actives where the bromo-alcohol motif enables modular synthetic strategies. Manufactured under controlled conditions, it supports drug discovery and materials science programs requiring precise control over thiophene substitution patterns.

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Product Name
(5-Bromothien-2-yl)methanol
CAS Number
79387-71-6
Chinese Name
(5-溴噻吩 -2-基) 甲醇
Synonyms
5-Bromo-2-thienylmethanol; (5-Bromo-2-thienyl)methanol; C₅H₅BrOS heterocycle; 5-Bromothiophene-2-methanol
Chinese Synonyms
5-溴 -2-噻吩甲醇; 5-溴噻吩 -2-甲醇; 溴代噻吩甲醇; 2-羟甲基 -5-溴噻吩
Molecular Formula
C₅H₅BrOS
Molecular Weight
193.06 g/mol (calculated: C5×12.01 + H5×1.008 + Br×79.90 + O×16.00 + S×32.07)
Purity
≥ 98% (GC/HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Thiophene Derivatives / Brominated Alcohols
Appearance
Colorless to Pale Yellow Liquid
Boiling Point
~260-270°C at 760 mmHg (estimated)
Density
~1.75 g/cm³ (estimated)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong oxidizing agents to avoid alcohol oxidation or sulfur oxidation.
Shelf Life
18-24 months under recommended storage conditions
Packaging
100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications
Thiophene oligomer synthesis (conducting polymers), kinase inhibitor scaffold development, cross-coupling reaction precursor (Suzuki/Stille), agrochemical active ingredient precursors, alcohol derivatization (oxidation/esterification)
Reactivity
Suitable for Pd-catalyzed cross-coupling (C5-Br), alcohol oxidation to aldehyde/acid, esterification, conversion to halides (for further coupling), and electrophilic aromatic substitution at C3/C4
Special Note
✅ Dual-Functionality Scaffold—C5-Br for coupling, C2-CH₂OH for derivatization. 2,5-substitution enables linear conjugation. Light-sensitive—brominated thiophenes may darken on exposure. Part of our thiophene building block series.

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]]> https://wealsunbio.com/product/5-bromothien-2-ylmethanol/feed/ 0 2-(Thiophen-3-yl)ethanol https://wealsunbio.com/product/2-thiophen-3-ylethanol/ https://wealsunbio.com/product/2-thiophen-3-ylethanol/#respond Sat, 24 Jan 2026 12:55:01 +0000 https://wealsunbio.com/?post_type=product&p=22339 2-(Thiophen-3-yl)ethanol (CAS 13781-67-4) is a strategically functionalized thiophene derivative engineered for pharmaceutical intermediate synthesis, ligand development, and materials science applications. This molecule integrates a 3-substituted thiophene core—a sulfur-containing five-membered heterocycle with excellent electron-donating properties and π-conjugation potential—with a 2-hydroxyethyl side chain at the C3 position. The primary alcohol terminus serves as a versatile handle for esterification, etherification, oxidation to aldehyde/acid, or conversion to halides for further cross-coupling strategies. The meta-like substitution pattern on the thiophene ring provides distinct electronic distribution compared to 2-substituted analogs, enabling unique binding orientations in target proteins. This intermediate is particularly valuable for constructing CNS-penetrant drug scaffolds, sulfur-containing ligands for metal coordination, and conductive polymer precursors where the thiophene-ethanol motif balances lipophilicity with synthetic flexibility. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to functionalized thiophene architectures with tunable physicochemical properties.

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Product Name
2-(Thiophen-3-yl)ethanol
CAS Number
13781-67-4
Chinese Name
2-(噻吩 -3-基) 乙醇
Synonyms
3-(2-Hydroxyethyl)thiophene; Thiophene-3-ethanol; 2-(3-Thienyl)ethanol; C₆H₈OS heterocycle
Chinese Synonyms
3-(2-羟乙基) 噻吩; 噻吩 -3-乙醇; 2-(3-噻吩基) 乙醇; 羟乙基噻吩
Molecular Formula
C₆H₈OS
Molecular Weight
128.19 g/mol
Purity
≥ 98% (GC area normalization)
Product Category
Pharmaceutical Intermediates / Thiophene Derivatives / Hydroxyalkyl Heterocycles
Appearance
Colorless to Pale Yellow Liquid
Boiling Point
~240-250°C at 760 mmHg (estimated)
Density
~1.15 g/cm³ at 20°C (estimated)
Refractive Index
n₂₀/D ~1.52 (estimated)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong oxidizing agents to avoid sulfur oxidation or alcohol degradation.
Shelf Life
24 months under recommended storage conditions
Packaging
100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications
Pharmaceutical intermediate synthesis, ligand development for metal coordination, conductive polymer precursor research, agrochemical active ingredient precursors, alcohol derivatization (esterification/etherification/oxidation)
Reactivity
Suitable for esterification, etherification, oxidation to aldehyde/acid, conversion to halides (for cross-coupling), electrophilic aromatic substitution at C2/C5, and sulfur oxidation to sulfone/sulfoxide
Special Note
✅ Versatile Thiophene Building Block—primary alcohol enables diverse derivatization strategies. 3-substitution pattern offers distinct electronic profile vs. 2-substituted thiophenes. Part of our thiophene building block series.

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