Piperidine|Piperidine compounds preparation supplier|Wealsun Biotech https://wealsunbio.com/product-category/piperidines/ Wed, 25 Feb 2026 07:14:03 +0000 en-US hourly 1 https://wordpress.org/?v=7.0 https://wealsunbio.com/wp-content/uploads/2025/06/20260211161228_5028_5-e1770797653670.png Piperidine|Piperidine compounds preparation supplier|Wealsun Biotech https://wealsunbio.com/product-category/piperidines/ 32 32 tert-butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate https://wealsunbio.com/product/tert-butyl-4-2-methoxy-2-oxoethylidenepiperidine-1-carboxylate/ https://wealsunbio.com/product/tert-butyl-4-2-methoxy-2-oxoethylidenepiperidine-1-carboxylate/#respond Sat, 24 Jan 2026 12:17:26 +0000 https://wealsunbio.com/?post_type=product&p=22238 tert-Butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate (CAS 169206-65-9) is a strategically functionalized Boc-protected piperidine derivative engineered for pharmaceutical intermediate synthesis, ligand development, and heterocyclic construction. This molecule integrates a saturated piperidine core—with an acid-labile Boc (tert-butoxycarbonyl) protecting group on the nitrogen atom (N1-position)—and an α,β-unsaturated methyl ester side chain at the C4 position (exocyclic double bond). The N-Boc protection prevents unwanted N-alkylation during synthetic sequences and can be removed under mild acidic conditions, while the conjugated ester moiety offers versatile reactivity including catalytic hydrogenation (to saturated methyl ester), Michael addition, or hydrolysis to the corresponding acid. Compared to its ethyl ester analog (CAS 135716-08-4), this methyl ester form offers slightly altered steric properties and hydrolysis kinetics, providing flexibility in synthetic route optimization. This intermediate is particularly valuable for constructing CNS-active pharmaceuticals, GPCR ligands, peptidomimetics, and piperidine-based scaffolds where controlled nitrogen reactivity and C4-functionalization are critical. Manufactured under controlled conditions, it supports drug discovery programs requiring modular access to differentially protected piperidine architectures with tunable side-chain reactivity.

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Product Name
tert-Butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate
CAS Number
169206-65-9
Chinese Name
叔丁基4-(2-甲氧基 -2-氧代亚乙基)哌啶-1-羧酸酯
Synonyms
Methyl (1-Boc-piperidin-4-ylidene)acetate; 1-Boc-4-(methoxycarbonylmethylene)piperidine; tert-Butyl 4-(2-methoxy-2-oxoethylidene)piperidine-1-carboxylate
Chinese Synonyms
1-Boc-4-(甲氧羰基亚甲基) 哌啶; 甲基(1-Boc-哌啶-4-亚基)乙酸酯; Boc-哌啶不饱和甲酯; 4-(2-甲氧基-2-氧代亚乙基)哌啶-1-羧酸叔丁酯
Molecular Formula
C₁₃H₂₁NO₄
Molecular Weight
255.31 g/mol
Purity
≥ 98% (HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Piperidine Derivatives / Protected Unsaturated Esters
Appearance
White to grayish-white solid
Boiling Point
~270-280°C at 760 mmHg (estimated)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong acids to avoid premature Boc deprotection and from strong oxidizing agents.
Shelf Life
18-24 months under recommended storage conditions
Packaging
100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications
CNS drug synthesis (GPCR ligands), peptidomimetic development, piperidine-based ligand construction, catalytic hydrogenation (to saturated methyl ester), Michael addition reactions, heterocyclic library synthesis
Reactivity
Suitable for selective Boc deprotection (TFA/HCl), ester hydrolysis (to acid), catalytic hydrogenation (to saturated methyl ester), Michael addition (conjugate addition), and sequential functionalization
Special Note
✅ Unsaturated Methyl Ester Scaffold—exocyclic double bond enables hydrogenation or Michael addition. Methyl ester vs. ethyl ester analog (CAS 135716-08-4) offers altered steric/hydrolysis properties. N-Boc enables orthogonal protection. Part of our protected piperidine building block series.

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]]> https://wealsunbio.com/product/tert-butyl-4-2-methoxy-2-oxoethylidenepiperidine-1-carboxylate/feed/ 0 tert-butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate https://wealsunbio.com/product/tert-butyl-4-2-ethoxy-2-oxoethylidenepiperidine-1-carboxylate/ https://wealsunbio.com/product/tert-butyl-4-2-ethoxy-2-oxoethylidenepiperidine-1-carboxylate/#respond Sat, 24 Jan 2026 12:16:52 +0000 https://wealsunbio.com/?post_type=product&p=22237 tert-Butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate (CAS 135716-08-4) is a strategically functionalized Boc-protected piperidine derivative engineered for pharmaceutical intermediate synthesis, ligand development, and heterocyclic construction. This molecule integrates a saturated piperidine core—with an acid-labile Boc (tert-butoxycarbonyl) protecting group on the nitrogen atom (N1-position)—and an α,β-unsaturated ethyl ester side chain at the C4 position (exocyclic double bond). The N-Boc protection prevents unwanted N-alkylation during synthetic sequences and can be removed under mild acidic conditions, while the conjugated ester moiety offers versatile reactivity including catalytic hydrogenation (to saturated ester), Michael addition, or hydrolysis to the corresponding acid. Compared to its saturated analogs (e.g., CAS 157688-46-5), this unsaturated precursor provides a strategic handle for introducing diversity at the C4 position via conjugate addition or reduction. This intermediate is particularly valuable for constructing CNS-active pharmaceuticals, GPCR ligands, peptidomimetics, and piperidine-based scaffolds where controlled nitrogen reactivity and C4-functionalization are critical. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to differentially protected piperidine architectures with tunable side-chain reactivity.

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Product Name
tert-Butyl 4-(2-ethoxy-2-oxoethylidene)piperidine-1-carboxylate
CAS Number
135716-08-4
Chinese Name
叔丁基 4-(2-乙氧基 -2-氧代亚乙基) 哌啶 -1-羧酸酯
Synonyms
Ethyl (1-Boc-piperidin-4-ylidene)acetate; 1-Boc-4-(ethoxycarbonylmethylene)piperidine; C₁₄H₂₃NO₄ protected unsaturated ester
Chinese Synonyms
1-Boc-4-(乙氧羰基亚甲基) 哌啶; 乙基 (1-Boc-哌啶 -4-亚基) 乙酸酯; Boc-哌啶不饱和酯; 保护性哌啶中间体
Molecular Formula
C₁₄H₂₃NO₄
Molecular Weight
269.34 g/mol 
Purity
≥ 98% (HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Piperidine Derivatives / Protected Unsaturated Esters
Appearance
White to off-white crystalline powder
Boiling Point
~280-290°C at 760 mmHg (estimated)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong acids to avoid premature Boc deprotection and from strong oxidizing agents.
Shelf Life
24 months under recommended storage conditions
Packaging
100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications
CNS drug synthesis (GPCR ligands), peptidomimetic development, piperidine-based ligand construction, catalytic hydrogenation (to saturated ester), Michael addition reactions, heterocyclic library synthesis
Reactivity
Suitable for selective Boc deprotection (TFA/HCl), ester hydrolysis (to acid), catalytic hydrogenation (to saturated ethyl ester), Michael addition (conjugate addition), and sequential functionalization
Special Note
✅ Unsaturated Ester Scaffold—exocyclic double bond enables hydrogenation or Michael addition. N-Boc enables orthogonal protection. Distinct from saturated analogs (CAS 157688-46-5) by unsaturation. Part of our protected piperidine building block series.

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]]> https://wealsunbio.com/product/tert-butyl-4-2-ethoxy-2-oxoethylidenepiperidine-1-carboxylate/feed/ 0 1-Boc-4-piperidylacetic acid https://wealsunbio.com/product/1-boc-4-piperidylacetic-acid/ https://wealsunbio.com/product/1-boc-4-piperidylacetic-acid/#respond Sat, 24 Jan 2026 12:16:27 +0000 https://wealsunbio.com/?post_type=product&p=22236 1-Boc-4-piperidylacetic acid (CAS 157688-46-5), also known as 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid, is a strategically protected piperidine-carboxylic acid derivative engineered for pharmaceutical intermediate synthesis, ligand development, and peptidomimetic construction. This molecule integrates a saturated piperidine core—with an acid-labile Boc (tert-butoxycarbonyl) protecting group on the nitrogen atom (N1-position)—and an acetic acid side chain at the C4 position. The N-Boc protection prevents unwanted N-alkylation during synthetic sequences and can be removed under mild acidic conditions, while the carboxylic acid terminus enables amide coupling, esterification, or salt formation for formulation optimization. Compared to its aminomethyl analog (CAS 144222-22-0), the acetic acid group provides direct access to amide/ester linkages with enhanced metabolic stability. Compared to its benzyl ester analog (CAS 177990-33-9), the free acid form offers immediate coupling capability without deprotection steps. This intermediate is particularly valuable for constructing CNS-active pharmaceuticals, GPCR ligands, peptidomimetics, and piperidine-based scaffolds where controlled nitrogen reactivity and carboxylic acid functionality are critical. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to differentially protected piperidine-carboxylic acid architectures.

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Product Name
1-Boc-4-piperidylacetic acid
CAS Number
157688-46-5
Chinese Name
1-Boc-4-哌啶基乙酸
Synonyms
2-(1-(tert-Butoxycarbonyl)piperidin-4-yl)acetic acid; N-Boc-piperidine-4-acetic acid; 1-Boc-piperidin-4-ylacetic acid; C₁₂H₂₁NO₄ protected acid
Chinese Synonyms
2-(1-叔丁氧羰基哌啶-4-基) 乙酸; N-Boc-哌啶-4-乙酸; 1-Boc-哌啶-4-基乙酸; Boc-哌啶乙酸
Molecular Formula
C₁₂H₂₁NO₄
Molecular Weight
243.30 g/mol 
Purity
≥ 98% (HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Piperidine Derivatives / Protected Carboxylic Acids
Appearance
Yellow to brown Crystalline Powder or Solid
Melting Point
~110-115°C (literature reference recommended)
pKa
~4.0-5.0 (carboxylic acid, estimated); ~9.5-10.0 (Boc-protected amine, non-basic)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong acids to avoid premature Boc deprotection and from strong bases to avoid salt formation.
Shelf Life
18-24 months under recommended storage conditions
Packaging
100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications
CNS drug synthesis (GPCR ligands), peptidomimetic development, piperidine-based ligand construction, amide coupling for drug conjugates, esterification for prodrug design, heterocyclic library synthesis
Reactivity
Suitable for selective Boc deprotection (TFA/HCl), carboxylic acid activation (EDC/HATU/DCC), esterification, amide coupling, salt formation, and sequential functionalization
Special Note
✅ Orthogonally Protected Acid Scaffold—N-Boc enables selective carboxylic acid modification before amine deprotection. Distinct from aminomethyl analog (CAS 144222-22-0) by acid vs. amine functionality. Distinct from benzyl ester (CAS 177990-33-9) by direct coupling capability. Part of our protected piperidine building block series.

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]]> https://wealsunbio.com/product/1-boc-4-piperidylacetic-acid/feed/ 0 4-(Aminomethyl)piperidine https://wealsunbio.com/product/4-aminomethylpiperidine/ https://wealsunbio.com/product/4-aminomethylpiperidine/#respond Sat, 24 Jan 2026 12:16:01 +0000 https://wealsunbio.com/?post_type=product&p=22235 4-(Aminomethyl)piperidine (CAS 7144-05-0), also known as 4-piperidinemethanamine, is a strategically functionalized piperidine derivative engineered for pharmaceutical intermediate synthesis, ligand development, and heterocyclic construction. This molecule integrates a saturated piperidine core—with a secondary amine at the N1-position—and a primary aminomethyl side chain at the C4 position. The dual amine architecture (secondary ring amine + primary side-chain amine) enables versatile orthogonal derivatization through selective alkylation, acylation, reductive amination, or heterocyclic fusion at either nitrogen center. Compared to its N-Boc protected analog (CAS 144222-22-0), this free base form offers direct reactivity without deprotection steps, making it suitable for streamlined synthetic routes. The 4-substitution pattern provides conformational flexibility and specific spatial orientation, making this intermediate particularly valuable for constructing CNS-active pharmaceuticals, GPCR ligands, peptidomimetics, and piperidine-based scaffolds where the diamine motif balances nucleophilicity with hydrogen-bonding capability. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to unprotected diamine architectures with defined reactivity patterns.

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Product Name
4-(Aminomethyl)piperidine
CAS Number
7144-05-0
Chinese Name
4-(氨基甲基) 哌啶
Synonyms
4-Piperidinemethanamine; Piperidine-4-methanamine; 4-(Aminomethyl)piperidine; C₆H₁₄N₂ diamine
Chinese Synonyms
4-哌啶甲胺; 哌啶 -4-甲胺; 4-氨基甲基哌啶; 氨基甲基哌啶二胺
Molecular Formula
C₆H₁₄N₂
Molecular Weight
114.19 g/mol 
Purity
≥ 98% (GC/HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Piperidine Derivatives / Diamine Building Blocks
Appearance
Colorless to Pale Yellow Liquid
Boiling Point
~200-210°C at 760 mmHg (estimated)
Density
~0.95 g/cm³ (estimated)
pKa
~10.5-11.0 (secondary amine), ~9.0-9.5 (primary amine, estimated)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong oxidizing agents to avoid amine oxidation.
Shelf Life
24 months under recommended storage conditions
Packaging
100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications
CNS drug synthesis (GPCR ligands), peptidomimetic development, piperidine-based ligand construction, heterocyclic library synthesis, side-chain amine functionalization (acylation/alkylation), ring nitrogen functionalization
Reactivity
Suitable for secondary amine alkylation/acylation, primary amine acylation/alkylation, reductive amination, heterocyclic cyclization, and selective/sequential diamine functionalization
Special Note
✅ Unprotected Diamine Scaffold—both amines (secondary ring + primary side-chain) are reactive. Distinct from N-Boc protected analog (CAS 144222-22-0) by direct reactivity without deprotection. Part of our piperidine building block series.

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]]> https://wealsunbio.com/product/4-aminomethylpiperidine/feed/ 0 4-Aminomethyl-1-N-Boc-piperidine https://wealsunbio.com/product/4-aminomethyl-1-n-boc-piperidine/ https://wealsunbio.com/product/4-aminomethyl-1-n-boc-piperidine/#respond Sat, 24 Jan 2026 12:15:35 +0000 https://wealsunbio.com/?post_type=product&p=22234 4-Aminomethyl-1-N-Boc-piperidine (CAS 144222-22-0), also known as tert-butyl 4-(aminomethyl)piperidine-1-carboxylate, is a strategically protected piperidine derivative engineered for pharmaceutical intermediate synthesis, ligand development, and combinatorial chemistry. This molecule integrates a saturated piperidine core—with an acid-labile Boc (tert-butoxycarbonyl) protecting group on the nitrogen atom (N1-position)—and a primary aminomethyl side chain at the C4 position. The N-Boc protection prevents unwanted N-alkylation during synthetic sequences and can be removed under mild acidic conditions, while the primary amine on the side chain offers orthogonal reactivity for acylation, alkylation, reductive amination, or heterocyclic fusion without affecting the protected ring nitrogen. Compared to its hydroxyethyl analog (CAS 89151-44-0), the aminomethyl group provides enhanced nucleophilicity and direct access to amide/urea linkages. This intermediate is particularly valuable for constructing CNS-active pharmaceuticals, GPCR ligands, peptidomimetics, and piperidine-based scaffolds where controlled nitrogen reactivity and side-chain functionalization are critical. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to differentially protected diamine architectures.

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Product Name
4-Aminomethyl-1-N-Boc-piperidine
CAS Number
144222-22-0
Chinese Name
4-氨基甲基 -1-N-Boc-哌啶
Synonyms
tert-Butyl 4-(aminomethyl)piperidine-1-carboxylate; N-Boc-4-aminomethylpiperidine; C₁₁H₂₂N₂O₂ protected piperidine
Chinese Synonyms
叔丁基 4-(氨基甲基) 哌啶 -1-羧酸酯; N-Boc-4-氨基甲基哌啶; Boc-氨基甲基哌啶; 保护性二胺中间体
Molecular Formula
C₁₁H₂₂N₂O₂
Molecular Weight
214.31 g/mol
Purity
≥ 98% (GC/HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Piperidine Derivatives / Protected Amines
Appearance
White to Off-white Crystalline Powder or Solid
Melting Point
~80-82°C (estimated, may exist as low-melting solid)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong acids to avoid premature Boc deprotection.
Shelf Life
24 months under recommended storage conditions
Packaging
100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications
CNS drug synthesis (GPCR ligands), peptidomimetic development, piperidine-based ligand construction, combinatorial chemistry library synthesis, side-chain amine functionalization (acylation/alkylation), orthogonal protection strategies
Reactivity
Suitable for selective Boc deprotection (TFA/HCl), side-chain amine acylation/alkylation, reductive amination, heterocyclic cyclization, and sequential functionalization
Special Note
✅ Orthogonally Protected Diamine—N-Boc enables selective side-chain amine modification before ring nitrogen deprotection. Distinct from hydroxyethyl analog (CAS 89151-44-0) by nucleophilicity. Part of our protected piperidine building block series.

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]]> https://wealsunbio.com/product/4-aminomethyl-1-n-boc-piperidine/feed/ 0 2-(Piperidin-2-yl)piperidine https://wealsunbio.com/product/2-piperidin-2-ylpiperidine/ https://wealsunbio.com/product/2-piperidin-2-ylpiperidine/#respond Sat, 24 Jan 2026 12:15:01 +0000 https://wealsunbio.com/?post_type=product&p=22233 2-(Piperidin-2-yl)piperidine (CAS 531-67-9), also known as 2,2'-bipiperidine, is a strategically symmetric bis-piperidine scaffold engineered for ligand development, pharmaceutical intermediate synthesis, and coordination chemistry applications. This molecule integrates two saturated piperidine rings connected at their respective C2 positions, creating a C₂-symmetric architecture with two secondary amine functionalities. The dual secondary amine structure enables versatile derivatization through alkylation, acylation, reductive amination, or heterocyclic fusion at both nitrogen centers. Compared to mono-piperidine analogs, this bis-piperidine scaffold offers enhanced chelating capability for metal coordination, distinct conformational flexibility, and specific spatial orientation for receptor binding. This intermediate is particularly valuable for constructing CNS-active pharmaceuticals, chiral ligands for asymmetric catalysis, GPCR modulators, and piperidine-based scaffolds where the bipiperidine motif provides unique binding geometry and metabolic stability. Manufactured under controlled conditions, it supports drug discovery programs requiring modular access to symmetric diamine architectures with defined stereochemistry.

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Product Name
2-(Piperidin-2-yl)piperidine
CAS Number
531-67-9
Chinese Name
2-(哌啶 -2-基) 哌啶
Synonyms
2,2′-Bipiperidine; Bis(2-piperidyl); Piperidine, 2,2′-bi-; C₁₀H₂₀N₂ diamine
Chinese Synonyms
2,2′-联哌啶; 双 (2-哌啶基); 2,2′-二哌啶; 联哌啶二胺
Molecular Formula
C₁₀H₂₀N₂
Molecular Weight
168.28 g/mol
Purity
≥ 98% (GC/HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Piperidine Derivatives / Diamine Ligands
Appearance
White to Almost white powder to lump ；White solid
Boiling Point
~260-270°C at 760 mmHg (estimated)
Density
~0.97 g/cm³ (estimated)
pKa
~10.0-11.0 (secondary amines, estimated)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong oxidizing agents to avoid amine oxidation.
Shelf Life
24 months under recommended storage conditions
Packaging
100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications
CNS drug synthesis (GPCR modulators), chiral ligand development for asymmetric catalysis, coordination chemistry (metal chelation), heterocyclic library construction, diamine functionalization (alkylation/acylation), pharmaceutical scaffold development
Reactivity
Suitable for secondary amine alkylation/acylation, reductive amination, heterocyclic cyclization, metal coordination, and symmetric/asymmetric derivatization at both nitrogen centers
Special Note
✅ Symmetric Bis-Piperidine Scaffold—two secondary amines enable dual functionalization. C2-symmetric architecture offers unique chelating capability vs. mono-piperidines. Part of our piperidine building block series.

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]]> https://wealsunbio.com/product/2-piperidin-2-ylpiperidine/feed/ 0 Benzyl n-boc-4-piperidinecarboxylate https://wealsunbio.com/product/benzyl-n-boc-4-piperidinecarboxylate/ https://wealsunbio.com/product/benzyl-n-boc-4-piperidinecarboxylate/#respond Sat, 20 Dec 2025 09:27:22 +0000 https://wealsunbio.com/?post_type=product&p=21955 Benzyl N-Boc-4-piperidinecarboxylate (CAS 177990-33-9), also known as 1-(tert-butoxycarbonyl)-4-(benzyloxycarbonyl)piperidine, is a strategically diprotected piperidine derivative engineered for pharmaceutical intermediate synthesis, combinatorial chemistry, and heterocyclic construction. This molecule integrates a saturated piperidine core with orthogonal protecting groups: an acid-labile Boc (tert-butoxycarbonyl) group on the nitrogen atom (N1-position) and a benzyl ester at the C4-position. The N-Boc protection prevents unwanted N-alkylation during synthetic sequences and can be removed under mild acidic conditions (TFA/HCl), while the benzyl ester can be selectively cleaved via hydrogenolysis (Pd/C, H₂) or strong acid treatment to liberate the carboxylic acid. This dual-protection architecture enables highly controlled sequential functionalization, allowing chemists to independently modify the nitrogen and C4-carboxyl positions. This intermediate is particularly valuable for constructing CNS-active pharmaceuticals, peptidomimetics, GPCR ligands, and piperidine-based scaffolds where orthogonal deprotection strategies are critical for multi-step synthesis. Manufactured under controlled conditions, it supports drug discovery programs requiring modular access to differentially protected piperidine architectures with defined reactivity patterns.

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Product Name
Benzyl N-Boc-4-piperidinecarboxylate
CAS Number
177990-33-9
Chinese Name
苯甲基 N-Boc-4-哌啶羧酸酯
Synonyms
1-Boc-4-(benzyloxycarbonyl)piperidine; Benzyl 1-(tert-butoxycarbonyl)piperidine-4-carboxylate; N-Boc-piperidine-4-carboxylic acid benzyl ester; C₁₈H₂₅NO₄ protected piperidine
Chinese Synonyms
1-Boc-4-(苄氧羰基)哌啶; 叔丁基 4-(苄氧基羰基)哌啶-1-羧酸酯; N-Boc-哌啶-4-羧酸苄酯; 双保护哌啶中间体
Molecular Formula
C₁₈H₂₅NO₄
Molecular Weight
319.40 g/mol 
Purity
≥ 98% (HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Piperidine Derivatives / Protected Amino Acid Esters
Appearance
White to Off-white Crystalline Powder or Solid
Melting Point
~65-69°C (literature reference recommended)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong acids to avoid premature Boc deprotection and from hydrogenation conditions to avoid benzyl ester cleavage.
Shelf Life
18-24 months under recommended storage conditions
Packaging
100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications
CNS drug synthesis (GPCR ligands), peptidomimetic development, piperidine-based ligand construction, combinatorial chemistry library synthesis, orthogonal deprotection strategies, heterocyclic library construction
Reactivity
Suitable for selective Boc deprotection (TFA/HCl), benzyl ester hydrogenolysis (Pd/C, H₂), ester transesterification, amide coupling (after deprotection), and sequential functionalization
Special Note
✅ Orthogonally Diprotected Scaffold—N-Boc (acid-labile) + benzyl ester (hydrogenolysis-labile) enable independent deprotection. Distinct from mono-protected analogs by synthetic flexibility. Part of our protected piperidine building block series.

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]]> https://wealsunbio.com/product/benzyl-n-boc-4-piperidinecarboxylate/feed/ 0 4-Piperidineethanol hydrochloride https://wealsunbio.com/product/4-piperidineethanol-hydrochloride/ https://wealsunbio.com/product/4-piperidineethanol-hydrochloride/#respond Sat, 20 Dec 2025 09:26:25 +0000 https://wealsunbio.com/?post_type=product&p=21954 4-Piperidineethanol hydrochloride (CAS 90747-17-4) is the hydrochloride salt form of 4-(2-hydroxyethyl)piperidine, engineered for pharmaceutical intermediate synthesis, ligand development, and heterocyclic construction. This molecule integrates a saturated piperidine core—with the secondary amine converted to a stable hydrochloride salt—and a 2-hydroxyethyl side chain at the C4 position. The hydrochloride salt form offers enhanced stability, improved crystallinity, better water solubility, and easier handling compared to the free base (CAS 622-26-4), making it particularly suitable for large-scale synthesis and long-term storage. The secondary amine hydrochloride can be readily liberated under basic conditions for alkylation, acylation, or reductive amination, while the primary alcohol terminus enables esterification, etherification, oxidation, or conversion to halides. This intermediate is particularly valuable for constructing CNS-active pharmaceuticals, opioid receptor modulators, and piperidine-based ligands where the salt form provides operational advantages during multi-step synthesis. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to stable, crystalline piperidine building blocks with defined protonation states.

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Product Name
4-Piperidineethanol hydrochloride
CAS Number
90747-17-4
Chinese Name
4-哌啶乙醇盐酸盐
Synonyms
2-(Piperidin-4-yl)ethanol hydrochloride; 4-(2-Hydroxyethyl)piperidine hydrochloride; Piperidine-4-ethanol HCl salt; C₇H₁₆ClNO hydrochloride
Chinese Synonyms
2-(哌啶-4-基) 乙醇盐酸盐; 4-(2-羟乙基) 哌啶盐酸盐; 哌啶-4-乙醇 HCl 盐; 羟乙基哌啶盐酸盐
Molecular Formula
C₇H₁₆ClNO
Molecular Weight
165.66 g/mol
Purity
≥ 98% (HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Piperidine Derivatives / Amine Hydrochloride Salts
Appearance
White to Off-white Crystalline Powder
Melting Point
~152°C (decomposition, literature reference recommended)
pH (1% aq.)
~4.0-5.5 (acidic due to HCl salt)
Solubility
Highly soluble in water (>100 mg/mL); soluble in methanol/ethanol; insoluble in non-polar solvents
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong bases to avoid salt liberation and from strong oxidizing agents.
Shelf Life
24 months under recommended storage conditions
Packaging
100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications
CNS drug synthesis (opioid receptor modulators), piperidine-based ligand development, heterocyclic library construction, alcohol derivatization (esterification/etherification/oxidation), amine functionalization (after base liberation), salt screening for drug development
Reactivity
Suitable for base-mediated amine liberation, alcohol esterification/etherification, oxidation to aldehyde/acid, conversion to halides, reductive amination (after neutralization), and heterocyclic cyclization
Special Note
✅ Hydrochloride Salt Form—enhanced stability and crystallinity vs. free base (CAS 622-26-4). Water-soluble for aqueous reactions. Requires base treatment to liberate free amine for N-functionalization. Part of our piperidine building block series.

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]]> https://wealsunbio.com/product/4-piperidineethanol-hydrochloride/feed/ 0 4-Piperidinepropanol https://wealsunbio.com/product/4-piperidinepropanol/ https://wealsunbio.com/product/4-piperidinepropanol/#respond Sat, 20 Dec 2025 09:26:00 +0000 https://wealsunbio.com/?post_type=product&p=21953 4-Piperidinepropanol (CAS 7037-49-2), also known as 3-(piperidin-4-yl)propan-1-ol, is a strategically functionalized piperidine derivative engineered for pharmaceutical intermediate synthesis, ligand development, and heterocyclic construction. This molecule integrates a saturated piperidine core—a six-membered nitrogen-containing heterocycle prevalent in bioactive molecules—with a 3-hydroxypropyl side chain at the C4 position. Distinct from its N-substituted isomer (CAS 104-58-5), this compound features a secondary amine at the N1-position, enabling direct acylation, alkylation, or reductive amination, while the primary alcohol terminus supports esterification, etherification, oxidation, or halogenation. The 3-carbon linker provides enhanced conformational flexibility compared to the 2-carbon analog (CAS 622-26-4), allowing optimized spatial arrangement in receptor binding pockets. This intermediate is particularly valuable for constructing CNS-active pharmaceuticals, opioid receptor modulators, and piperidine-based ligands where the secondary amine + hydroxypropyl motif balances lipophilicity with orthogonal derivatization potential. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to C4-substituted piperidine architectures with defined chain lengths.

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Product Name
4-Piperidinepropanol
CAS Number
7037-49-2
Chinese Name
4-哌啶丙醇
Synonyms
3-(Piperidin-4-yl)propan-1-ol; 4-(3-Hydroxypropyl)piperidine; Piperidine-4-propanol; C₈H₁₇NO heterocycle
Chinese Synonyms
3-(哌啶-4-基)-1-丙醇; 4-(3-羟丙基)哌啶; 哌啶-4-丙醇; 羟丙基哌啶
Molecular Formula
C₈H₁₇NO
Molecular Weight
143.23 g/mol 
Purity
≥ 98% (GC/HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Piperidine Derivatives / Hydroxyalkyl Amines
Appearance
Colorless to Pale Yellow Solid
Boiling Point
~235°C at 760 mmHg (estimated)
Density
~0.98 g/cm³ (estimated)
pKa
~10.5-11.0 (secondary amine, estimated)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong oxidizing agents to avoid amine oxidation or alcohol degradation.
Shelf Life
24 months under recommended storage conditions
Packaging
100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications
CNS drug synthesis (opioid receptor modulators), piperidine-based ligand development, heterocyclic library construction, alcohol derivatization (esterification/etherification/oxidation), amine functionalization (alkylation/acylation), prodrug design
Reactivity
Suitable for secondary amine alkylation/acylation, alcohol esterification/etherification, oxidation to aldehyde/acid, conversion to halides, reductive amination, and heterocyclic cyclization
Special Note
✅ C4-Substituted Secondary Amine—distinct from N-substituted isomer (CAS 104-58-5, tertiary amine). 3-Carbon linker offers enhanced flexibility vs. 2-carbon analog (CAS 622-26-4). Part of our piperidine building block series.

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]]> https://wealsunbio.com/product/4-piperidinepropanol/feed/ 0 1-Boc-4-(2-hydroxyethyl)piperidine https://wealsunbio.com/product/1-boc-4-2-hydroxyethylpiperidine/ https://wealsunbio.com/product/1-boc-4-2-hydroxyethylpiperidine/#respond Sat, 20 Dec 2025 09:25:00 +0000 https://wealsunbio.com/?post_type=product&p=21952 1-Boc-4-(2-hydroxyethyl)piperidine (CAS 89151-44-0), also known as tert-butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate, is a strategically protected piperidine derivative engineered for pharmaceutical intermediate synthesis, ligand development, and heterocyclic construction. This molecule integrates a saturated piperidine core—with a acid-labile Boc (tert-butoxycarbonyl) protecting group on the nitrogen atom—and a 2-hydroxyethyl side chain at the C4 position. The N-Boc protection ensures compatibility with base-sensitive reactions and prevents unwanted N-alkylation during synthetic sequences, while the primary alcohol terminus enables esterification, etherification, oxidation, or conversion to halides for further functionalization. This orthogonal protection strategy allows chemists to selectively modify the hydroxyethyl side chain before deprotecting the piperidine nitrogen under mild acidic conditions. Compared to its unprotected analog (CAS 622-26-4), this compound offers enhanced stability during multi-step synthesis and improved purification profiles. This intermediate is particularly valuable for constructing CNS-active pharmaceuticals, GPCR ligands, and piperidine-based scaffolds where controlled nitrogen reactivity is critical. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to differentially protected piperidine architectures.

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Product Name
1-Boc-4-(2-hydroxyethyl)piperidine
CAS Number
89151-44-0
Chinese Name
1-Boc-4-(2-羟乙基) 哌啶
Synonyms
tert-Butyl 4-(2-hydroxyethyl)piperidine-1-carboxylate; N-Boc-4-(2-hydroxyethyl)piperidine; C₁₂H₂₃NO₃ protected piperidine
Chinese Synonyms
叔丁基 4-(2-羟乙基) 哌啶 -1-羧酸酯; N-Boc-4-(2-羟乙基) 哌啶; Boc-羟乙基哌啶; 保护性哌啶中间体
Molecular Formula
C₁₂H₂₃NO₃
Molecular Weight
229.32 g/mol 
Purity
≥ 98% (GC/HPLC area normalization)
Product Category
Pharmaceutical Intermediates / Piperidine Derivatives / Protected Amines
Appearance
Colorless to pale yellow viscous liquid
Melting Point
~50-55°C (estimated, may exist as low-melting solid)
Storage Conditions
Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong acids to avoid premature Boc deprotection.
Shelf Life
18-24 months under recommended storage conditions
Packaging
100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications
CNS drug synthesis (GPCR ligands), piperidine-based ligand development, heterocyclic library construction, alcohol derivatization (esterification/etherification/oxidation), sequential functionalization via orthogonal Boc/OH protection
Reactivity
Suitable for selective Boc deprotection (TFA/HCl), alcohol esterification/etherification, oxidation to aldehyde/acid, conversion to halides, and heterocyclic cyclization
Special Note
✅ Orthogonally Protected Scaffold—N-Boc enables selective side-chain modification before amine deprotection. Distinct from unprotected analog (CAS 622-26-4) by stability and purification profile. Part of our protected piperidine building block series.

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