1-(2-CHLOROETHYL)-4-FLUOROBENZENE

1-(2-Chloroethyl)-4-fluorobenzene (CAS 332-43-4), also known as 4-Fluorophenethyl chloride or p-Fluorophenethyl chloride, is a high-purity fluorinated benzene derivative intermediate widely used in pharmaceutical synthesis, organic chemistry research, and fine chemical manufacturing. This compound features a fluorine substituent at the para-position and a chloroethyl side chain on the benzene ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in nucleophilic substitution reactions, cross-coupling chemistry, and functional group transformations, it exhibits excellent reactivity in Williamson ether synthesis, alkylation reactions, and Suzuki coupling pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing para-fluorinated aromatic structures, CNS-active drug intermediates, and agrochemical precursors. As a reliable benzene derivative intermediate, it serves as an important precursor for constructing fluorine-protected phenolic scaffolds in drug discovery and specialty chemical development programs.

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Product Name	1-(2-Chloroethyl)-4-fluorobenzene
CAS Number	332-43-4
Chinese Name	1-(2-氯乙基)-4-氟苯
Synonyms	4-Fluorophenethyl chloride; p-Fluorophenethyl chloride; 1-Chloro-2-(4-fluorophenyl)ethane; Benzene, 1-(2-chloroethyl)-4-fluoro-; 2-(4-Fluorophenyl)ethyl chloride; 4-Fluoro-β-chloroethylbenzene; p-FC₆H₄CH₂CH₂Cl; 1-(2-Chloroethyl)-4-fluorobenzene; 4-Fluorophenethyl chloride; β-Chloro-4-fluorophenethyl
Chinese Synonyms	对氟苯乙基氯; 4-氟苯乙基氯; 1-氯-2-(4-氟苯基)乙烷; 2-(4-氟苯基)氯乙烷; 对氟-β-氯乙苯; 4-氟-β-氯乙基苯
Molecular Formula	C₈H₈ClF
Molecular Weight	158.60 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Fluorinated Alkyl Halides
Appearance	Colorless to Light Yellow Liquid
Boiling Point	~190-195°C (estimated)
Density	~1.15 g/cm³ (estimated)
Refractive Index	n₂₀/D ~1.50 (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from oxidation and strong bases.
Shelf Life	24 months under recommended storage conditions
Packaging	25kg/drum, 50kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, nucleophilic substitution, cross-coupling reactions, CNS drug development, fluorinated aromatic compound synthesis, agrochemical intermediates
Reactivity	Suitable for nucleophilic substitution, alkylation reactions, Williamson ether synthesis, Suzuki coupling, Heck reaction, and para-fluoro-directed functionalization