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1-Piperidinepropanol
1-Piperidinepropanol (CAS 104-58-5), also known as 3-(1-piperidinyl)-1-propanol, is a strategically functionalized N-substituted piperidine derivative engineered for pharmaceutical intermediate synthesis, ligand development, and polymer additive applications. This molecule integrates a saturated piperidine core—a six-membered nitrogen-containing heterocycle prevalent in bioactive molecules—with a 3-hydroxypropyl side chain attached directly to the nitrogen atom (N1-position). The tertiary amine nitrogen provides basicity and nucleophilicity for salt formation or quaternization, while the primary alcohol terminus enables esterification, etherification, oxidation to aldehyde/acid, or conversion to halides for further functionalization. Compared to C-substituted piperidines (e.g., CAS 622-26-4), the N-substitution pattern offers distinct electronic properties, enhanced metabolic stability at the amine center, and reduced steric hindrance around the ring carbons. This intermediate is particularly valuable for constructing CNS-active pharmaceuticals, antihistamines, muscle relaxants, and polymer stabilizers where the piperidinyl-propanol motif balances lipophilicity with hydrogen-bonding capability. Manufactured under controlled conditions, it supports drug discovery programs requiring modular access to tertiary amino-alcohol architectures with orthogonal derivatization pathways.
Property
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Product Name
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1-Piperidinepropanol
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CAS Number
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104-58-5
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Chinese Name
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1-哌啶丙醇
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Synonyms
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3-(1-Piperidinyl)-1-propanol; 1-(3-Hydroxypropyl)piperidine; N-(3-Hydroxypropyl)piperidine; C₈H₁₇NO heterocycle
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Chinese Synonyms
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3-(1-哌啶基)-1-丙醇; 1-(3-羟丙基) 哌啶; N-(3-羟丙基) 哌啶; 哌啶丙醇
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Molecular Formula
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C₈H₁₇NO
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Molecular Weight
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143.23 g/mol
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Purity
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≥ 98% (GC/HPLC area normalization)
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Product Category
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Pharmaceutical Intermediates / Piperidine Derivatives / Tertiary Amino Alcohols
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Appearance
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Colorless to Pale Yellow Liquid
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Boiling Point
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~250-260°C at 760 mmHg (estimated)
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Density
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~0.99 g/cm³ at 20°C (estimated)
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pKa
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~10.0-10.5 (tertiary amine, estimated)
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Storage Conditions
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Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong oxidizing agents to avoid amine oxidation (N-oxide) or alcohol degradation.
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Shelf Life
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24 months under recommended storage conditions
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Packaging
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100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
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Applications
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CNS drug synthesis (antihistamines/muscle relaxants), tertiary amine ligand development, polymer additive precursor (UV stabilizers), alcohol derivatization (esterification/etherification/oxidation), quaternary ammonium salt synthesis
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Reactivity
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Suitable for alcohol esterification/etherification, oxidation to aldehyde/acid, conversion to halides, amine salt formation, quaternization, N-oxide formation, and heterocyclic cyclization
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Special Note
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✅ N-Substituted Tertiary Amine—distinct from C-substituted secondary amines (CAS 622-26-4). Dual reactivity (tertiary amine + primary alcohol). Part of our piperidine building block series.
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