2-(Piperidin-2-yl)piperidine

2-(Piperidin-2-yl)piperidine (CAS 531-67-9), also known as 2,2′-bipiperidine, is a strategically symmetric bis-piperidine scaffold engineered for ligand development, pharmaceutical intermediate synthesis, and coordination chemistry applications. This molecule integrates two saturated piperidine rings connected at their respective C2 positions, creating a C₂-symmetric architecture with two secondary amine functionalities. The dual secondary amine structure enables versatile derivatization through alkylation, acylation, reductive amination, or heterocyclic fusion at both nitrogen centers. Compared to mono-piperidine analogs, this bis-piperidine scaffold offers enhanced chelating capability for metal coordination, distinct conformational flexibility, and specific spatial orientation for receptor binding. This intermediate is particularly valuable for constructing CNS-active pharmaceuticals, chiral ligands for asymmetric catalysis, GPCR modulators, and piperidine-based scaffolds where the bipiperidine motif provides unique binding geometry and metabolic stability. Manufactured under controlled conditions, it supports drug discovery programs requiring modular access to symmetric diamine architectures with defined stereochemistry.

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Product Name	2-(Piperidin-2-yl)piperidine
CAS Number	531-67-9
Chinese Name	2-(哌啶 -2-基) 哌啶
Synonyms	2,2′-Bipiperidine; Bis(2-piperidyl); Piperidine, 2,2′-bi-; C₁₀H₂₀N₂ diamine
Chinese Synonyms	2,2′-联哌啶; 双 (2-哌啶基); 2,2′-二哌啶; 联哌啶二胺
Molecular Formula	C₁₀H₂₀N₂
Molecular Weight	168.28 g/mol
Purity	≥ 98% (GC/HPLC area normalization)
Product Category	Pharmaceutical Intermediates / Piperidine Derivatives / Diamine Ligands
Appearance	White to Almost white powder to lump ；White solid
Boiling Point	~260-270°C at 760 mmHg (estimated)
Density	~0.97 g/cm³ (estimated)
pKa	~10.0-11.0 (secondary amines, estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong oxidizing agents to avoid amine oxidation.
Shelf Life	24 months under recommended storage conditions
Packaging	100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
Applications	CNS drug synthesis (GPCR modulators), chiral ligand development for asymmetric catalysis, coordination chemistry (metal chelation), heterocyclic library construction, diamine functionalization (alkylation/acylation), pharmaceutical scaffold development
Reactivity	Suitable for secondary amine alkylation/acylation, reductive amination, heterocyclic cyclization, metal coordination, and symmetric/asymmetric derivatization at both nitrogen centers
Special Note	✅ Symmetric Bis-Piperidine Scaffold—two secondary amines enable dual functionalization. C2-symmetric architecture offers unique chelating capability vs. mono-piperidines. Part of our piperidine building block series.