2-(Piperidin-4-yl)ethanol

2-(Piperidin-4-yl)ethanol (CAS 622-26-4) is a strategically functionalized piperidine derivative engineered for pharmaceutical intermediate synthesis, ligand development, and heterocyclic construction. This molecule integrates a saturated piperidine core—a six-membered nitrogen-containing heterocycle prevalent in bioactive molecules—with a 2-hydroxyethyl side chain at the C4 position. The secondary amine nitrogen serves as a versatile handle for alkylation, acylation, reductive amination, or heterocyclic fusion, while the primary alcohol terminus enables esterification, etherification, oxidation to aldehyde/acid, or conversion to halides for further functionalization. The 4-substitution pattern provides conformational flexibility and specific spatial orientation, making it particularly valuable for constructing CNS-active pharmaceuticals, opioid receptor modulators, and piperidine-based ligands where the hydroxyethyl-piperidine motif balances lipophilicity with hydrogen-bonding capability. Compared to 2- or 3-substituted piperidines, the 4-position offers reduced steric hindrance and distinct binding geometries. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to functionalized piperidine architectures with orthogonal derivatization pathways.