3-BROMO-4-CHLORO-5-NITROPYRIDINE

3-Bromo-4-chloro-5-nitropyridine (CAS 31872-63-6), also known as Pyridine, 3-bromo-4-chloro-5-nitro- or 3-Bromo-4-chloro-5-nitro-1-azabenzene, is a high-purity polyhalogenated nitropyridine intermediate widely used in pharmaceutical synthesis, organic chemistry research, agrochemical development, and fine chemical manufacturing. This compound features a bromine substituent at the 3-position, a chlorine atom at the 4-position, and a nitro group at the 5-position of the pyridine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic aromatic substitution, and nitro group reduction, it exhibits excellent reactivity in Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, and selective halogen displacement pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, kinase inhibitor synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing polyhalogenated nitropyridine scaffolds, heterocyclic kinase inhibitor intermediates, agrochemical precursors, and specialty chemical precursors. As a reliable pyridine derivative intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.

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Product Name	3-Bromo-4-chloro-5-nitropyridine
CAS Number	31872-63-6
Chinese Name	3-溴-4-氯-5-硝基吡啶
Synonyms	Pyridine, 3-bromo-4-chloro-5-nitro-; 3-Bromo-4-chloro-5-nitro-1-azabenzene; C₅H₂BrClN₂O₂ heterocycle; MFCD07368836
Chinese Synonyms	3-溴-4-氯-5-硝基-1-氮杂苯; 溴氯硝基吡啶; 3-溴-4-氯-5-硝基吡啶
Molecular Formula	C₅H₂BrClN₂O₂
Molecular Weight	237.44 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Pyridine Derivatives / Polyhalogenated Nitropyridines
Appearance	Yellow to Brown Crystalline Powder or Solid
Melting Point	49-50°C (literature)
Boiling Point	~285°C at 760 mmHg (estimated)
Density	~1.94 g/cm³ (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen or argon). Protect from strong oxidizing agents and reducing agents. Store at 2-8°C for extended stability.
Shelf Life	24 months under recommended storage conditions
Packaging	100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, kinase inhibitor synthesis, heterocyclic chemistry, nitro reduction to amino, cross-coupling reactions, selective halogen displacement, agrochemical intermediates, fine chemical production
Reactivity	Suitable for Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, nucleophilic aromatic substitution (preferential Br/Cl displacement), catalytic hydrogenation (nitro to amino), and halogen-directed ortho-functionalization