3-Bromo-4-hydroxy-5-nitropyridine

3-Bromo-4-hydroxy-5-nitropyridine (CAS 31872-65-8), also known as 3-Bromo-5-nitropyridin-4-ol or Pyridine, 3-bromo-4-hydroxy-5-nitro-, is a high-purity bromo-hydroxy-nitro substituted pyridine intermediate widely used in pharmaceutical synthesis, organic chemistry research, agrochemical development, and fine chemical manufacturing. This compound features a bromine substituent at the 3-position, a hydroxyl group at the 4-position, and a nitro group at the 5-position of the pyridine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic aromatic substitution, nitro group reduction, and hydroxyl group derivatization, it exhibits excellent reactivity in Suzuki coupling, Buchwald-Hartwig amination, catalytic hydrogenation, and selective bromine displacement pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, kinase inhibitor synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing polyfunctionalized pyridine scaffolds, heterocyclic kinase inhibitor intermediates, agrochemical precursors, and specialty chemical precursors. As a reliable pyridine derivative intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.

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Product Name	3-Bromo-4-hydroxy-5-nitropyridine
CAS Number	31872-65-8
Chinese Name	3-溴-4-羟基-5-硝基吡啶
Synonyms	3-Bromo-5-nitropyridin-4-ol; Pyridine, 3-bromo-4-hydroxy-5-nitro-; 3-Bromo-4-hydroxy-5-nitro-1-azabenzene; C₅H₃BrN₂O₃ heterocycle; MFCD08692339
Chinese Synonyms	3-溴-5-硝基吡啶-4-醇; 3-溴-4-羟基-5-硝基-1-氮杂苯; 溴羟基硝基吡啶; 3-溴-4-羟基-5-硝基吡啶
Molecular Formula	C₅H₃BrN₂O₃
Molecular Weight	218.99 g/mol
Purity	≥ 98% (HPLC/GC)
Product Category	Pharmaceutical Intermediates / Pyridine Derivatives / Polyfunctionalized Nitropyridines
Appearance	Yellow to Brown Crystalline Powder or Solid
Melting Point	~150-155°C (estimated, decomposition)
Boiling Point	~341.8°C at 760 mmHg (estimated)
Density	~2.0 g/cm³ (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen or argon). Protect from strong oxidizing agents and reducing agents. Store at room temperature or 2-8°C for extended stability.
Shelf Life	24 months under recommended storage conditions
Packaging	100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, kinase inhibitor synthesis, heterocyclic chemistry, nitro reduction to amino, cross-coupling reactions, selective bromine displacement, hydroxyl group derivatization, agrochemical intermediates, fine chemical production
Reactivity	Suitable for Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, nucleophilic aromatic substitution (preferential Br displacement), catalytic hydrogenation (nitro to amino), hydroxyl group etherification/esterification, and halogen-directed ortho-functionalization