3,5-Di-tert-butylaniline

3,5-Di-tert-butylaniline (CAS 2380-36-1), also known as 3,5-Bis(1,1-dimethylethyl)aniline or 3,5-Di-tert-butylbenzenamine, is a high-purity sterically-hindered aromatic amine intermediate widely used in pharmaceutical synthesis, organic chemistry research, polymer chemistry, and fine chemical manufacturing. This compound features two tert-butyl groups at the meta-positions of the aniline structure, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in electrophilic aromatic substitution, amide coupling, and functional group transformations, it exhibits excellent reactivity in diazotization, nucleophilic substitution, and cross-coupling pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, antioxidant synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing sterically-hindered aromatic amine scaffolds, polymer stabilizers, agrochemical intermediates, and specialty chemical precursors. As a reliable benzene derivative intermediate, it serves as an important precursor for constructing bulky aromatic amine systems in drug discovery and fine chemical development programs.

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Product Name	3,5-Di-tert-butylaniline
CAS Number	2380-36-1
Chinese Name	3,5-二叔丁基苯胺
Synonyms	3,5-Bis(1,1-dimethylethyl)aniline; 3,5-Di-tert-butylbenzenamine; Benzenamine, 3,5-bis(1,1-dimethylethyl)-; 3,5-Di-tert-butylphenylamine; 1-Amino-3,5-di-tert-butylbenzene; 3,5-Di-t-butylaniline; 3,5-Bis(tert-butyl)aniline; 3,5-(t-Bu)₂C₆H₃NH₂
Chinese Synonyms	3,5-双(1,1-二甲基乙基)苯胺; 3,5-二叔丁基苯基胺; 1-氨基-3,5-二叔丁基苯; 3,5-二特丁基苯胺; 间二叔丁基苯胺
Molecular Formula	C₁₄H₂₃N
Molecular Weight	205.34 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Sterically-Hindered Anilines
Appearance	Colorless to Light Yellow Liquid or Low-Melting Solid
Boiling Point	~280-285°C (estimated)
Density	~0.92 g/cm³ (estimated)
Refractive Index	n₂₀/D ~1.51 (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from oxidation and strong oxidizing agents.
Shelf Life	24 months under recommended storage conditions
Packaging	25kg/drum, 50kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, polymer stabilizers, antioxidant synthesis, agrochemical intermediates, electrophilic aromatic substitution, amide coupling, fine chemical production
Reactivity	Suitable for diazotization, nucleophilic substitution, amide bond formation, electrophilic aromatic substitution, Suzuki coupling, and sterically-directed ortho-functionalization