3,5-DI-TERT-BUTYLBENZOIC ACID

3,5-Di-tert-butylbenzoic acid (CAS 16225-26-6) is a high-purity sterically-hindered benzoic acid derivative widely used in pharmaceutical synthesis, organic chemistry research, polymer chemistry, and fine chemical manufacturing. This compound features two tert-butyl groups at the meta-positions of the benzoic acid structure, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in esterification, amide coupling, and functional group transformations, it exhibits excellent reactivity in Friedel-Crafts acylation, cross-coupling reactions, and decarboxylation pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, ligand synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing sterically-hindered aromatic carboxylic acid scaffolds, organocatalyst precursors, agrochemical intermediates, and specialty chemical precursors.

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Product Name	3,5-Di-tert-butylbenzoic acid
CAS Number	16225-26-6
Chinese Name	3,5-二叔丁基苯甲酸
Synonyms	3,5-Bis(1,1-dimethylethyl)benzoic acid; Benzoic acid, 3,5-bis(1,1-dimethylethyl)-; 3,5-Di-tert-butylbenzenecarboxylic acid; 3,5-Di-t-butylbenzoic acid; 3,5-Bis(tert-butyl)benzoic acid; 5-Carboxy-1,3-di-tert-butylbenzene; 3,5-(t-Bu)₂C₆H₃COOH
Chinese Synonyms	3,5-双(1,1-二甲基乙基)苯甲酸; 3,5-二特丁基苯甲酸; 间二叔丁基苯甲酸; 5-羧基-1,3-二叔丁基苯
Molecular Formula	C₁₅H₂₂O₂
Molecular Weight	234.33 g/mol
Purity	≥ 98% (HPLC/GC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Sterically-Hindered Benzoic Acids
Appearance	White to Off-white Crystalline Powder
Melting Point	165-170°C (literature)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases.
Shelf Life	24 months under recommended storage conditions
Packaging	1kg/foil bag, 5kg/drum, 25kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, ligand synthesis, organocatalyst precursors, esterification reactions, amide coupling, agrochemical intermediates, fine chemical production
Reactivity	Suitable for esterification, amide bond formation, decarboxylation, Friedel-Crafts reactions, Suzuki coupling, and sterically-directed ortho-functionalization