3,5-DI-TERT-BUTYLBENZOIC ACID METHYL ESTER

Methyl 3,5-di-tert-butylbenzoate (CAS 64277-87-8) is a high-purity sterically-hindered benzoate ester intermediate widely used in pharmaceutical synthesis, organic chemistry research, polymer chemistry, and fine chemical manufacturing. This compound features two tert-butyl groups at the meta-positions of the methyl benzoate structure, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in esterification, hydrolysis, and functional group transformations, it exhibits excellent reactivity in Friedel-Crafts acylation, cross-coupling reactions, and transesterification pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, ligand synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing sterically-hindered aromatic ester scaffolds, organocatalyst precursors, agrochemical intermediates, and specialty chemical precursors.

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Product Name	Methyl 3,5-di-tert-butylbenzoate
CAS Number	64277-87-8
Chinese Name	3,5-二叔丁基苯甲酸甲酯
Synonyms	Methyl 3,5-bis(1,1-dimethylethyl)benzoate; Benzoic acid, 3,5-bis(1,1-dimethylethyl)-, methyl ester; 3,5-Di-tert-butylbenzoic acid methyl ester; Methyl 3,5-di-t-butylbenzoate; 3,5-Bis(tert-butyl)benzoic acid methyl ester; 5-(Methoxycarbonyl)-1,3-di-tert-butylbenzene; 3,5-(t-Bu)₂C₆H₃COOCH₃
Chinese Synonyms	3,5-二特丁基苯甲酸甲酯; 间二叔丁基苯甲酸甲酯; 3,5-双(1,1-二甲基乙基)苯甲酸甲酯; 5-甲氧羰基-1,3-二叔丁基苯; 3,5-二叔丁基苯甲酸甲酯
Molecular Formula	C₁₆H₂₄O₂
Molecular Weight	248.36 g/mol
Purity	≥ 98% (HPLC/GC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Sterically-Hindered Benzoates
Appearance	Colorless to Light Yellow Liquid or Low-Melting Solid
Boiling Point	~290-295°C (estimated)
Density	~0.96 g/cm³ (estimated)
Refractive Index	n₂₀/D ~1.50 (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong acids and bases.
Shelf Life	24 months under recommended storage conditions
Packaging	1kg/foil bag, 5kg/drum, 25kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, ligand synthesis, organocatalyst precursors, esterification reactions, hydrolysis to acid, agrochemical intermediates, fine chemical production
Reactivity	Suitable for hydrolysis to carboxylic acid, transesterification, Friedel-Crafts reactions, Suzuki coupling, and sterically-directed ortho-functionalization