3,5-DI-TERT-BUTYLTOLUENE

3,5-Di-tert-butyltoluene (CAS 15181-11-0), also known as 1-Methyl-3,5-di-tert-butylbenzene or 3,5-Bis(1,1-dimethylethyl)toluene, is a high-purity sterically-hindered aromatic hydrocarbon intermediate widely used in pharmaceutical synthesis, organic chemistry research, polymer chemistry, and fine chemical manufacturing. This compound features two tert-butyl groups at the meta-positions and a methyl substituent on the benzene ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in Friedel-Crafts alkylation, electrophilic aromatic substitution, and functional group transformations, it exhibits excellent reactivity in cross-coupling reactions, benzylic oxidation, and radical substitution pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, ligand synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing sterically-hindered aromatic scaffolds, polymer stabilizer precursors, agrochemical intermediates, and specialty chemical precursors. As a reliable benzene derivative intermediate, it serves as an important precursor for constructing bulky aromatic systems in drug discovery and fine chemical development programs.

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Product Name	3,5-Di-tert-butyltoluene
CAS Number	15181-11-0
Chinese Name	3,5-二叔丁基甲苯
Synonyms	1-Methyl-3,5-di-tert-butylbenzene; 3,5-Bis(1,1-dimethylethyl)toluene; Benzene, 1-methyl-3,5-bis(1,1-dimethylethyl)-; 3,5-Di-tert-butyl-1-methylbenzene; 3,5-Di-t-butyltoluene; 3,5-Bis(tert-butyl)toluene; 1,3-Di-tert-butyl-5-methylbenzene; 3,5-(t-Bu)₂C₆H₃CH₃
Chinese Synonyms	1-甲基-3,5-二叔丁基苯; 3,5-双(1,1-二甲基乙基)甲苯; 3,5-二特丁基甲苯; 1,3-二叔丁基-5-甲基苯; 间二叔丁基甲苯
Molecular Formula	C₁₅H₂₄
Molecular Weight	204.35 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Sterically-Hindered Aromatics
Appearance	Colorless to Light Yellow Liquid
Boiling Point	~250-255°C (estimated)
Density	~0.88 g/cm³ (estimated)
Refractive Index	n₂₀/D ~1.49 (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and acids.
Shelf Life	24 months under recommended storage conditions
Packaging	25kg/drum, 50kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, polymer stabilizers, ligand synthesis, Friedel-Crafts reactions, benzylic functionalization, agrochemical intermediates, fine chemical production
Reactivity	Suitable for benzylic oxidation, electrophilic aromatic substitution, Suzuki coupling, Heck reaction, radical bromination, and sterically-directed ortho-functionalization