4-(Benzyloxy)-1-bromo-2-fluorobenzene

4-(Benzyloxy)-1-bromo-2-fluorobenzene (CAS 185346-79-6), also known as 1-Bromo-2-fluoro-4-(phenylmethoxy)benzene or 4-Benzyloxy-2-fluorobromobenzene, is a high-purity multi-substituted fluorinated aromatic intermediate widely used in pharmaceutical synthesis, organic chemistry research, and fine chemical manufacturing. This compound features a benzyloxy group at the para-position, a bromine substituent at position 1, and a fluorine atom at the ortho-position of the benzene ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic aromatic substitution, and functional group transformations, it exhibits excellent reactivity in Suzuki coupling, Sonogashira coupling, Buchwald-Hartwig amination, and benzyloxy deprotection pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing multi-halogenated aromatic scaffolds, kinase inhibitor intermediates, fluorinated drug precursors, and specialty chemical precursors. As a reliable benzene derivative intermediate from our product line, it serves as an important precursor for constructing functionalized aromatic systems in drug discovery and fine chemical development programs.

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Product Name	4-(Benzyloxy)-1-bromo-2-fluorobenzene
CAS Number	185346-79-6
Chinese Name	4-(苄氧基)-1-溴-2-氟苯
Synonyms	1-Bromo-2-fluoro-4-(phenylmethoxy)benzene; 4-Benzyloxy-2-fluorobromobenzene; Benzene, 1-bromo-2-fluoro-4-(phenylmethoxy)-; 2-Fluoro-4-(benzyloxy)bromobenzene; 1-Bromo-4-(benzyloxy)-2-fluorobenzene; 4-(Benzyloxy)-2-fluoro-1-bromobenzene; p-Benzyloxy-o-fluorobromobenzene; BFB-BOB
Chinese Synonyms	1-溴-2-氟-4-(苯甲氧基)苯; 4-苄氧基-2-氟溴苯; 2-氟-4-苄氧基溴苯; 对苄氧基邻氟溴苯; 1-溴-4-苄氧基-2-氟苯
Molecular Formula	C₁₃H₁₀BrFO
Molecular Weight	281.12 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Fluorinated Bromoarenes
Appearance	Colorless to Light Yellow Liquid or Low-Melting Solid
Boiling Point	~310-315°C (estimated)
Density	~1.45 g/cm³ (estimated)
Refractive Index	n₂₀/D ~1.56 (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases.
Shelf Life	24 months under recommended storage conditions
Packaging	25kg/drum, 50kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, Suzuki/Sonogashira/Buchwald-Hartwig cross-coupling, fluorinated drug development, nucleophilic aromatic substitution, benzyloxy protection chemistry, fine chemical production
Reactivity	Suitable for Suzuki coupling, Sonogashira coupling, Buchwald-Hartwig amination, nucleophilic aromatic substitution, benzyloxy deprotection (hydrogenolysis), and halogen-directed ortho-functionalization