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4-bromo-2-hydroxyacetophenone
4-Bromo-2-hydroxyacetophenone (CAS 30186-18-6) is a high-purity brominated hydroxyacetophenone intermediate widely used in pharmaceutical synthesis and organic chemistry research. This compound features a bromine substituent at the para-position and a hydroxyl group at the ortho-position of the acetophenone structure, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in heterocyclic synthesis, condensation reactions, and functional group transformations, it exhibits excellent reactivity in Friedel-Crafts acylation, Claisen-Schmidt condensation, and cyclization reactions. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing brominated phenolic structures, benzofuran derivatives, and chromone-based APIs.
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Product Name
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4-Bromo-2-hydroxyacetophenone
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CAS Number
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30186-18-6
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Chinese Name
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4-溴-2-羟基苯乙酮
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Synonyms
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1-(4-Bromo-2-hydroxyphenyl)ethanone; 2′-Hydroxy-4′-bromoacetophenone; Ethanone, 1-(4-bromo-2-hydroxyphenyl)-; 4-Bromosalicyloyl methyl ketone; o-Hydroxy-p-bromoacetophenone; 4-Bromo-2-hydroxyphenyl methyl ketone; 2-Hydroxy-4-bromoacetophenone
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Chinese Synonyms
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2-羟基-4-溴苯乙酮; 1-(4-溴-2-羟基苯基)乙酮; 4-溴邻羟基苯乙酮; 邻羟基对溴苯乙酮
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Molecular Formula
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C₈H₇BrO₂
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Molecular Weight
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215.04 g/mol
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Purity
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≥ 98%
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Product Category
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Pharmaceutical Intermediates / Acetophenone Derivatives / Brominated Phenols
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Appearance
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White to Off-white Crystalline Powder
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Melting Point
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135-138°C (literature)
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Storage Conditions
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Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from oxidation.
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Shelf Life
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24 months under recommended storage conditions
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Packaging
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1kg/foil bag, 5kg/drum, 25kg/drum, or customized according to customer requirements
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Applications
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Pharmaceutical intermediates, organic synthesis, API manufacturing, heterocyclic synthesis, benzofuran/chromone preparation, condensation reactions
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Reactivity
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Suitable for Claisen-Schmidt condensation, cyclization reactions, etherification, esterification, and nucleophilic substitution reactions
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Special Note
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Key intermediate for benzofuran and chromone scaffold synthesis
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