4-Chloro-2-nitrobenzyl alcohol

4-Chloro-2-nitrobenzyl alcohol (CAS 22996-18-5), also known as (4-Chloro-2-nitrophenyl)methanol or 2-Nitro-4-chlorobenzyl alcohol, is a high-purity chloro-nitro substituted benzyl alcohol intermediate widely used in pharmaceutical synthesis, organic chemistry research, and fine chemical manufacturing. This compound features a chlorine substituent at the para-position and a nitro group at the ortho-position of the benzyl alcohol structure, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in reduction reactions, nucleophilic substitution, and functional group transformations, it exhibits excellent reactivity in catalytic hydrogenation (nitro to amino), esterification, etherification, and cross-coupling pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing chloro-nitro aromatic scaffolds, heterocyclic intermediates, agrochemical precursors, and specialty chemical precursors. As a reliable benzene derivative intermediate from our product line, it serves as an important precursor for constructing functionalized aromatic systems in drug discovery and fine chemical development programs.

Property

Product Name	4-Chloro-2-nitrobenzyl alcohol
CAS Number	22996-18-5
Chinese Name	4-氯-2-硝基苯甲醇
Synonyms	(4-Chloro-2-nitrophenyl)methanol; 2-Nitro-4-chlorobenzyl alcohol; Benzyl alcohol, 4-chloro-2-nitro-; 4-Chloro-2-nitrophenylmethanol; 2-Nitro-4-chloro-α-hydroxytoluene; 1-(Hydroxymethyl)-4-chloro-2-nitrobenzene; p-Chloro-o-nitrobenzyl alcohol; 4-Cl-2-NO₂-benzyl alcohol
Chinese Synonyms	2-硝基-4-氯苄醇; 4-氯-2-硝基苄醇; 1-(羟甲基)-4-氯-2-硝基苯; 对氯邻硝基苯甲醇; 4-氯-2-硝基-α-羟基甲苯
Molecular Formula	C₇H₆ClNO₃
Molecular Weight	187.58 g/mol
Purity	≥ 98% (HPLC)
Product Category	Pharmaceutical Intermediates / Benzene Derivatives / Nitrobenzyl Alcohols
Appearance	Light Yellow to Yellow Crystalline Powder or Solid
Melting Point	75-80°C (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and reducing agents.
Shelf Life	24 months under recommended storage conditions
Packaging	1kg/foil bag, 5kg/drum, 25kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, nitro reduction reactions, nucleophilic substitution, esterification, etherification, heterocyclic synthesis, agrochemical intermediates, fine chemical production
Reactivity	Suitable for catalytic hydrogenation (nitro to amino), esterification, etherification, nucleophilic substitution, oxidation to aldehyde/acid, and chloro/nitro-directed ortho-functionalization