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4-Fluoro-2-hydroxyacethophenone
4-Fluoro-2-hydroxyacetophenone (CAS 1481-27-2) is a high-purity fluorinated hydroxyacetophenone intermediate widely used in pharmaceutical synthesis and organic chemistry research. This compound features a fluorine substituent at the para-position and a hydroxyl group at the ortho-position of the acetophenone structure, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in heterocyclic synthesis, condensation reactions, and functional group transformations, it exhibits excellent reactivity in Friedel-Crafts acylation, Claisen-Schmidt condensation, and cyclization reactions. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, and scale-up production. This compound is particularly valuable in the synthesis of fluorinated pharmaceuticals, benzofuran derivatives, chromone-based APIs, and agrochemical intermediates.
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Product Name
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4-Fluoro-2-hydroxyacetophenone
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CAS Number
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1481-27-2
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Chinese Name
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4-氟-2-羟基苯乙酮
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Synonyms
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1-(4-Fluoro-2-hydroxyphenyl)ethanone; 2′-Hydroxy-4′-fluoroacetophenone; Ethanone, 1-(4-fluoro-2-hydroxyphenyl)-; 4-Fluorosalicyloyl methyl ketone; o-Hydroxy-p-fluoroacetophenone; 4-Fluoro-2-hydroxyphenyl methyl ketone; 2-Hydroxy-4-fluoroacetophenone; 4-F-2-OH-acetophenone
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Chinese Synonyms
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2-羟基-4-氟苯乙酮; 1-(4-氟-2-羟基苯基)乙酮; 4-氟邻羟基苯乙酮; 邻羟基对氟苯乙酮; 4-氟-2-羟基乙酰苯
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Molecular Formula
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C₈H₇FO₂
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Molecular Weight
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154.14 g/mol
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Purity
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≥ 98% (HPLC)
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Product Category
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Pharmaceutical Intermediates / Acetophenone Derivatives / Fluorinated Phenols
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Appearance
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White to Off-white Crystalline Powder
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Melting Point
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118-122°C (literature)
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Storage Conditions
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Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from oxidation.
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Shelf Life
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24 months under recommended storage conditions
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Packaging
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1kg/foil bag, 5kg/drum, 25kg/drum, or customized according to customer requirements
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Applications
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Pharmaceutical intermediates, organic synthesis, API manufacturing, heterocyclic synthesis, benzofuran/chromone preparation, fluorinated drug development, agrochemical intermediates
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Reactivity
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Suitable for Claisen-Schmidt condensation, cyclization reactions, etherification, esterification, nucleophilic substitution, and fluorine-directed ortho-metalation
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