4-Hydroxy-3-nitropyridine

4-Hydroxy-3-nitropyridine (CAS 5435-54-1), also known as 3-Nitropyridin-4-ol or 3-Nitro-4-pyridinol, is a high-purity hydroxy-nitro substituted pyridine intermediate widely used in pharmaceutical synthesis, organic chemistry research, agrochemical development, and fine chemical manufacturing. This compound features a hydroxyl group at the 4-position and a nitro group at the 3-position of the pyridine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in nucleophilic aromatic substitution, nitro group reduction, and hydroxyl group derivatization, it exhibits excellent reactivity in catalytic hydrogenation, etherification, esterification, and heterocyclic functionalization pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, kinase inhibitor synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing hydroxynitropyridine scaffolds, heterocyclic kinase inhibitor intermediates, agrochemical precursors, and specialty chemical precursors. As a reliable pyridine derivative intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.

Property

Product Name	4-Hydroxy-3-nitropyridine
CAS Number	5435-54-1
Chinese Name	4-羟基-3-硝基吡啶
Synonyms	3-Nitropyridin-4-ol; 3-Nitro-4-pyridinol; Pyridin-4-ol, 3-nitro-; 3-Nitro-4-hydroxypyridine; C₅H₄N₂O₃ heterocycle; MFCD00128874
Chinese Synonyms	3-硝基吡啶-4-醇; 3-硝基-4-羟基吡啶; 4-羟基-3-硝基吡啶; 硝基羟基吡啶
Molecular Formula	C₅H₄N₂O₃
Molecular Weight	140.10 g/mol
Purity	≥ 98% (HPLC/GC)
Product Category	Pharmaceutical Intermediates / Pyridine Derivatives / Hydroxynitropyridines
Appearance	Yellow to Brown Crystalline Powder or Solid
Melting Point	285°C (decomposition, literature)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and reducing agents. Store sealed at 2-8°C for extended stability.
Shelf Life	24 months under recommended storage conditions
Packaging	100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, kinase inhibitor synthesis, heterocyclic chemistry, nitro reduction to amino, hydroxyl group derivatization, agrochemical intermediates, fine chemical production
Reactivity	Suitable for catalytic hydrogenation (nitro to amino), nucleophilic aromatic substitution, hydroxyl group etherification/esterification, electrophilic aromatic substitution, and heterocyclic ring functionalization