4-Methyl-2-Hydroxyacetophenone

4-Methyl-2-hydroxyacetophenone (CAS 6921-64-8) is a high-purity methylated hydroxyacetophenone intermediate widely used in pharmaceutical synthesis, organic chemistry research, and fine chemical manufacturing. This compound features a methyl substituent at the para-position and a hydroxyl group at the ortho-position of the acetophenone structure, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in heterocyclic synthesis, condensation reactions, and functional group transformations, it exhibits excellent reactivity in Claisen-Schmidt condensation, Friedel-Crafts acylation, and cyclization reactions. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing methylated phenolic structures, benzofuran derivatives, chromone-based APIs, and agrochemical intermediates.

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Product Name	4-Methyl-2-hydroxyacetophenone
CAS Number	6921-64-8
Chinese Name	4-甲基-2-羟基苯乙酮
Synonyms	2′-Hydroxy-4′-methylacetophenone; 1-(2-Hydroxy-4-methylphenyl)ethanone; Ethanone, 1-(2-hydroxy-4-methylphenyl)-; 4-Methylsalicyloyl methyl ketone; o-Hydroxy-p-methylacetophenone; 2-Hydroxy-4-methylacetophenone; 4-Methyl-2-hydroxyphenyl methyl ketone; 4-Me-2-OH-acetophenone
Chinese Synonyms	2-羟基-4-甲基苯乙酮; 1-(2-羟基-4-甲基苯基)乙酮; 4-甲基邻羟基苯乙酮; 邻羟基对甲基苯乙酮; 4-甲基-2-羟基乙酰苯
Molecular Formula	C₉H₁₀O₂
Molecular Weight	150.17 g/mol
Purity	≥ 98% (HPLC)
Product Category	Pharmaceutical Intermediates / Acetophenone Derivatives / Methylated Phenols
Appearance	White to Off-white Crystalline Powder or Light Yellow Solid
Melting Point	78-82°C (literature)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from oxidation.
Shelf Life	24 months under recommended storage conditions
Packaging	1kg/foil bag, 5kg/drum, 25kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, heterocyclic synthesis, benzofuran/chromone preparation, methylated drug development, agrochemical intermediates, fine chemical production
Reactivity	Suitable for Claisen-Schmidt condensation, cyclization reactions, etherification, esterification, nucleophilic substitution, and methyl-directed ortho-functionalization