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4-Piperidinepropanol
4-Piperidinepropanol (CAS 7037-49-2), also known as 3-(piperidin-4-yl)propan-1-ol, is a strategically functionalized piperidine derivative engineered for pharmaceutical intermediate synthesis, ligand development, and heterocyclic construction. This molecule integrates a saturated piperidine core—a six-membered nitrogen-containing heterocycle prevalent in bioactive molecules—with a 3-hydroxypropyl side chain at the C4 position. Distinct from its N-substituted isomer (CAS 104-58-5), this compound features a secondary amine at the N1-position, enabling direct acylation, alkylation, or reductive amination, while the primary alcohol terminus supports esterification, etherification, oxidation, or halogenation. The 3-carbon linker provides enhanced conformational flexibility compared to the 2-carbon analog (CAS 622-26-4), allowing optimized spatial arrangement in receptor binding pockets. This intermediate is particularly valuable for constructing CNS-active pharmaceuticals, opioid receptor modulators, and piperidine-based ligands where the secondary amine + hydroxypropyl motif balances lipophilicity with orthogonal derivatization potential. Manufactured with purity ≥98% under controlled conditions, it supports drug discovery programs requiring modular access to C4-substituted piperidine architectures with defined chain lengths.
Property
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Product Name
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4-Piperidinepropanol
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CAS Number
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7037-49-2
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Chinese Name
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4-哌啶丙醇
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Synonyms
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3-(Piperidin-4-yl)propan-1-ol; 4-(3-Hydroxypropyl)piperidine; Piperidine-4-propanol; C₈H₁₇NO heterocycle
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Chinese Synonyms
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3-(哌啶-4-基)-1-丙醇; 4-(3-羟丙基)哌啶; 哌啶-4-丙醇; 羟丙基哌啶
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Molecular Formula
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C₈H₁₇NO
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Molecular Weight
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143.23 g/mol
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Purity
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≥ 98% (GC/HPLC area normalization)
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Product Category
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Pharmaceutical Intermediates / Piperidine Derivatives / Hydroxyalkyl Amines
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Appearance
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Colorless to Pale Yellow Solid
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Boiling Point
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~235°C at 760 mmHg (estimated)
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Density
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~0.98 g/cm³ (estimated)
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pKa
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~10.5-11.0 (secondary amine, estimated)
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Storage Conditions
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Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen). Protect from strong oxidizing agents to avoid amine oxidation or alcohol degradation.
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Shelf Life
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24 months under recommended storage conditions
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Packaging
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100mg/vial, 500mg/vial, 1g/bottle, 5g/bottle, or customized according to customer requirements
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Applications
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CNS drug synthesis (opioid receptor modulators), piperidine-based ligand development, heterocyclic library construction, alcohol derivatization (esterification/etherification/oxidation), amine functionalization (alkylation/acylation), prodrug design
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Reactivity
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Suitable for secondary amine alkylation/acylation, alcohol esterification/etherification, oxidation to aldehyde/acid, conversion to halides, reductive amination, and heterocyclic cyclization
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Special Note
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✅ C4-Substituted Secondary Amine—distinct from N-substituted isomer (CAS 104-58-5, tertiary amine). 3-Carbon linker offers enhanced flexibility vs. 2-carbon analog (CAS 622-26-4). Part of our piperidine building block series.
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