5-Bromo-2-chloropyrimidine

5-Bromo-2-chloropyrimidine (CAS 32779-36-5), also known as 2-Chloro-5-bromopyrimidine or Pyrimidine, 5-bromo-2-chloro-, is a high-purity dihalogenated heterocyclic intermediate widely used in pharmaceutical synthesis, organic chemistry research, nucleoside chemistry, and fine chemical manufacturing. This compound features a bromine substituent at the 5-position and a chlorine atom at the 2-position of the pyrimidine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic aromatic substitution, and heterocyclic functionalization, it exhibits excellent reactivity in Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, and selective halogen displacement pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, antiviral drug synthesis, kinase inhibitor development, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing dihalogenated pyrimidine scaffolds, nucleoside analog precursors, heterocyclic kinase inhibitor intermediates, and specialty chemical precursors. As a reliable heterocyclic intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.

Property

Product Name	5-Bromo-2-chloropyrimidine
CAS Number	32779-36-5
Chinese Name	5-溴-2-氯嘧啶
Synonyms	2-Chloro-5-bromopyrimidine; Pyrimidine, 5-bromo-2-chloro-; 5-Bromo-2-chloro-1,3-diazine; C₄H₂BrClN₂ heterocycle; MFCD00483232
Chinese Synonyms	2-氯-5-溴嘧啶; 5-溴-2-氯-1,3-二氮杂苯; 溴氯嘧啶; 5-溴-2-氯吡嗪
Molecular Formula	C₄H₂BrClN₂
Molecular Weight	193.43 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Heterocyclic Compounds / Dihalogenated Pyrimidines
Appearance	Off-white to Light Yellow Crystalline Powder or Solid
Melting Point	76-81°C (literature)
Boiling Point	95°C/15mmHg or ~291.6°C at 760 mmHg (estimated)
Density	~1.9 g/cm³ (estimated)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases. Store sealed at room temperature or 2-8°C.
Shelf Life	24 months under recommended storage conditions
Packaging	100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, nucleoside synthesis, antiviral drug development, kinase inhibitor synthesis, heterocyclic chemistry, selective halogen displacement reactions, agrochemical intermediates
Reactivity	Suitable for Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, nucleophilic aromatic substitution (preferential Cl displacement), electrophilic aromatic substitution