5-Bromo-2-hydroxypyrimidine

5-Bromo-2-hydroxypyrimidine (CAS 38353-06-9), also known as 5-Bromo-2(1H)-pyrimidinone or 2(1H)-Pyrimidinone, 5-bromo-, is a high-purity brominated hydroxypyrimidine intermediate widely used in pharmaceutical synthesis, organic chemistry research, nucleoside chemistry, and fine chemical manufacturing. This compound features a bromine substituent at the 5-position and a hydroxyl group at the 2-position of the pyrimidine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic substitution, and heterocyclic functionalization, it exhibits excellent reactivity in Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, and electrophilic aromatic substitution pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, antiviral drug synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing brominated pyrimidine scaffolds, kinase inhibitor intermediates, nucleoside analog precursors, and specialty chemical precursors. As a reliable heterocyclic intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.

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Product Name	5-Bromo-2-hydroxypyrimidine
CAS Number	38353-06-9
Chinese Name	5-溴-2-羟基嘧啶
Synonyms	5-Bromo-2(1H)-pyrimidinone; 2(1H)-Pyrimidinone, 5-bromo-; 5-Bromopyrimidin-2-ol; 5-Bromo-1H-pyrimidin-2-one; 2-Hydroxy-5-bromopyrimidine; Pyrimidin-2(1H)-one, 5-bromo-; 5-Bromo-2-pyrimidinol; C₄H₃BrN₂O heterocycle
Chinese Synonyms	5-溴嘧啶-2-酮; 2-羟基-5-溴嘧啶; 5-溴-1H-嘧啶-2-酮; 溴代羟基嘧啶; 5-溴-2-吡啶酮
Molecular Formula	C₄H₃BrN₂O
Molecular Weight	174.98 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Heterocyclic Compounds / Hydroxypyrimidines
Appearance	Pale Yellow to Light Yellow Crystalline Powder or Solid
Melting Point	~230°C (decomposition, literature) chemsavers.com
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases.
Shelf Life	24 months under recommended storage conditions
Packaging	100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, nucleoside synthesis, antiviral drug development, kinase inhibitor synthesis, heterocyclic chemistry, aldehyde oxidase inhibitor research, agrochemical intermediates, fine chemical production
Reactivity	Suitable for Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, nucleophilic substitution, electrophilic aromatic substitution, bromine-directed ortho-functionalization, and hydroxyl group derivatization