5-Bromo-2-iodopyridine

5-Bromo-2-iodopyridine (CAS 223463-13-6), also known as 2-Iodo-5-bromopyridine or Pyridine, 5-bromo-2-iodo-, is a high-purity dihalogenated pyridine intermediate widely used in pharmaceutical synthesis, organic chemistry research, and fine chemical manufacturing. This compound features a bromine substituent at the 5-position and an iodine atom at the 2-position of the pyridine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic aromatic substitution, and heterocyclic functionalization, it exhibits excellent reactivity in Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, Stille coupling, and selective halogen displacement pathways (preferential iodine displacement). Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, kinase inhibitor synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing dihalogenated pyridine scaffolds, heterocyclic kinase inhibitor intermediates, and specialty chemical precursors. As a reliable pyridine derivative intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.

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Product Name	5-Bromo-2-iodopyridine
CAS Number	223463-13-6
Chinese Name	5-溴-2-碘吡啶
Synonyms	2-Iodo-5-bromopyridine; Pyridine, 5-bromo-2-iodo-; 5-Bromo-2-iodo-1-azabenzene; C₅H₃BrIN heterocycle; MFCD00691506
Chinese Synonyms	2-碘-5-溴吡啶; 5-溴-2-碘-1-氮杂苯; 溴碘吡啶; 5-溴-2-碘吡啶
Molecular Formula	C₅H₃BrIN
Molecular Weight	283.89 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Pyridine Derivatives / Dihalogenated Pyridines
Appearance	White to Light Brown Crystalline Powder or Solid
Melting Point	113-117°C (literature)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases. Store sealed under inert atmosphere (nitrogen or argon) at 2-8°C for extended stability.
Shelf Life	24 months under recommended storage conditions
Packaging	100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, kinase inhibitor synthesis, heterocyclic chemistry, selective halogen displacement reactions (preferential I displacement), agrochemical intermediates, fine chemical production
Reactivity	Suitable for Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, Stille coupling, nucleophilic aromatic substitution (preferential iodine displacement), electrophilic aromatic substitution, and halogen-directed ortho-functionalization