5-Bromo-2-iodopyrimidine

5-Bromo-2-iodopyrimidine (CAS 183438-24-6), also known as 2-Iodo-5-bromopyrimidine or Pyrimidine, 5-bromo-2-iodo-, is a high-purity dihalogenated heterocyclic intermediate widely used in pharmaceutical synthesis, organic chemistry research, nucleoside chemistry, and fine chemical manufacturing. This compound features a bromine substituent at the 5-position and an iodine atom at the 2-position of the pyrimidine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic aromatic substitution, and heterocyclic functionalization, it exhibits excellent reactivity in Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, Stille coupling, and selective halogen displacement pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, antiviral drug synthesis, kinase inhibitor development, VEGFR-2 inhibitor synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing dihalogenated pyrimidine scaffolds, nucleoside analog precursors, heterocyclic kinase inhibitor intermediates, and specialty chemical precursors. As a reliable heterocyclic intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.

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Product Name	5-Bromo-2-iodopyrimidine
CAS Number	183438-24-6
Chinese Name	5-溴-2-碘嘧啶
Synonyms	2-Iodo-5-bromopyrimidine; Pyrimidine, 5-bromo-2-iodo-; 5-Bromo-2-iodo-1,3-diazine; C₄H₂BrIN₂ heterocycle; MFCD01318111
Chinese Synonyms	2-碘-5-溴嘧啶; 5-溴-2-碘-1,3-二氮杂苯; 溴碘嘧啶; 5-溴-2-碘吡嗪; 5-溴-2-碘嘧啶
Molecular Formula	C₄H₂BrIN₂
Molecular Weight	284.88 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Heterocyclic Compounds / Dihalogenated Pyrimidines
Appearance	Off-white to White Crystalline Powder or Solid
Melting Point	99-103°C (literature)
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases. Store sealed at room temperature or 2-8°C for extended stability.
Shelf Life	24 months under recommended storage conditions
Packaging	100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, nucleoside synthesis, antiviral drug development, kinase inhibitor synthesis, VEGFR-2 inhibitor research, heterocyclic chemistry, selective halogen displacement reactions, agrochemical intermediates
Reactivity	Suitable for Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, Stille coupling, nucleophilic aromatic substitution (preferential I displacement), electrophilic aromatic substitution, and halogen-directed ortho-functionalization