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Ethyl nicotinate
Ethyl nicotinate (CAS 614-18-6), also known as Ethyl 3-pyridinecarboxylate or Nicotinic acid ethyl ester, is a high-purity pyridine carboxylate ester intermediate widely used in pharmaceutical synthesis, organic chemistry research, cosmetic formulation, agrochemical development, and fine chemical manufacturing. This compound features an ethyl ester group at the 3-position of the pyridine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in ester hydrolysis, amidation, and nucleophilic substitution, it exhibits excellent reactivity in conversion to nicotinic acid derivatives, niacinamide synthesis, and heterocyclic functionalization pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, cosmetic ingredient production (as a rubefacient/skin conditioning agent), and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing pyridine-3-carboxylate scaffolds, vitamin B3 derivatives, cosmetic active ingredients, and specialty chemical precursors. As a reliable pyridine derivative intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.
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Product Name
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Ethyl nicotinate
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CAS Number
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614-18-6
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Chinese Name
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烟酸乙酯
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Synonyms
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Ethyl 3-pyridinecarboxylate; Nicotinic acid ethyl ester; 3-Pyridinecarboxylic acid ethyl ester; Pyridine-3-carboxylic acid, ethyl ester; C₈H₉NO₂ heterocycle; MFCD00006389
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Chinese Synonyms
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3-吡啶羧酸乙酯; 烟酸乙酯; 尼古丁酸乙酯; 吡啶-3-甲酸乙酯; 尼克酸乙酯
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Molecular Formula
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C₈H₉NO₂
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Molecular Weight
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151.16 g/mol www.sigmaaldrich.com
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Purity
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≥ 98% (GC/HPLC)
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Product Category
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Pharmaceutical Intermediates / Pyridine Derivatives / Nicotinate Esters
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Appearance
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Colorless to Light Yellow Liquid or Low-Melting Solid
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Boiling Point
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~245-250°C at 760 mmHg (estimated)
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Density
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~1.12 g/cm³ (estimated)
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Refractive Index
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n₂₀/D ~1.52 (estimated)
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Storage Conditions
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Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases. Store sealed at 2-8°C for extended stability.
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Shelf Life
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24 months under recommended storage conditions
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Packaging
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100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
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Applications
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Pharmaceutical intermediates, organic synthesis, API manufacturing, cosmetic ingredient production (rubefacient), vitamin B3 derivative synthesis, ester hydrolysis to nicotinic acid, amidation to niacinamide, agrochemical intermediates, fine chemical production
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Reactivity
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Suitable for ester hydrolysis to acid, amidation to amide, nucleophilic substitution, electrophilic aromatic substitution, and pyridine ring functionalization
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