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Methyl 2,6-dichloro-5-fluoronicotinate
Methyl 2,6-dichloro-5-fluoronicotinate (CAS 189281-66-1), also known as Methyl 2,6-dichloro-5-fluoropyridine-3-carboxylate, is a high-purity polyhalogenated pyridine ester intermediate widely used in pharmaceutical synthesis, organic chemistry research, agrochemical development, and fine chemical manufacturing. This compound features chlorine substituents at the 2- and 6-positions, a fluorine atom at the 5-position, and a methyl ester group at the 3-position of the pyridine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic aromatic substitution, and ester hydrolysis, it exhibits excellent reactivity in Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, and selective halogen displacement pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, kinase inhibitor synthesis, herbicide intermediate production, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing polyhalogenated pyridine scaffolds, agrochemical precursors, heterocyclic kinase inhibitor intermediates, and specialty chemical precursors. As a reliable pyridine derivative intermediate from our product line, it serves as an important precursor for constructing functionalized halogenated aromatic systems in drug discovery and fine chemical development programs.
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Product Name
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Methyl 2,6-dichloro-5-fluoronicotinate
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CAS Number
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189281-66-1
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Chinese Name
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2,6-二氯-5-氟烟酸甲酯
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Synonyms
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Methyl 2,6-dichloro-5-fluoropyridine-3-carboxylate; Pyridine-3-carboxylic acid, 2,6-dichloro-5-fluoro-, methyl ester; 2,6-Dichloro-5-fluoronicotinic acid methyl ester; C₇H₄Cl₂FNO₂ heterocycle; MFCD02180634
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Chinese Synonyms
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甲基2,6-二氯-5-氟烟酸酯; 2,6-二氯-5-氟吡啶-3-甲酸甲酯; 2,6-二氯-5-氟烟酸甲酯; 二氯氟烟酸甲酯
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Molecular Formula
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C₇H₄Cl₂FNO₂
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Molecular Weight
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224.02 g/mol
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Purity
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≥ 98% (GC/HPLC)
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Product Category
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Pharmaceutical Intermediates / Pyridine Derivatives / Polyhalogenated Nicotinates
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Appearance
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White to Off-white Crystalline Powder or Solid
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Boiling Point
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84°C (literature)
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Density
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1.506±0.06 g/cm³ (predicted)
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Vapor Pressure
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0.00704 mmHg at 25°C
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Storage Conditions
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Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases. Store under inert gas (nitrogen or argon) at 2-8°C for extended stability.
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Shelf Life
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24 months under recommended storage conditions
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Packaging
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100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
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Applications
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Pharmaceutical intermediates, organic synthesis, API manufacturing, kinase inhibitor synthesis, herbicide development, agrochemical intermediates, cross-coupling reactions, nucleophilic aromatic substitution, fine chemical production
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Reactivity
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Suitable for Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, nucleophilic aromatic substitution (preferential Cl/F displacement), ester hydrolysis, and halogen-directed ortho-functionalization
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