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Methyl 6-methoxypicolinate
Methyl 6-methoxypicolinate (CAS 26256-72-4), also known as Methyl 6-methoxypyridine-2-carboxylate or 6-Methoxy-2-pyridinecarboxylic acid methyl ester, is a high-purity methoxypyridine ester intermediate widely used in pharmaceutical synthesis, organic chemistry research, agrochemical development, and fine chemical manufacturing. This compound features a methoxy substituent at the 6-position and a methyl ester group at the 2-position of the pyridine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in ester hydrolysis, nucleophilic aromatic substitution, and cross-coupling reactions, it exhibits excellent reactivity in Suzuki coupling, Buchwald-Hartwig amination, amide formation, and selective methoxy displacement pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, kinase inhibitor synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing methoxypyridine scaffolds, heterocyclic kinase inhibitor intermediates, agrochemical precursors, and specialty chemical precursors. As a reliable pyridine derivative intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.
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Product Name
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Methyl 6-methoxypicolinate
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CAS Number
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26256-72-4
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Chinese Name
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6-甲氧基吡啶-2-羧酸甲酯
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Synonyms
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Methyl 6-methoxypyridine-2-carboxylate; 6-Methoxy-2-pyridinecarboxylic acid methyl ester; Pyridine-2-carboxylic acid, 6-methoxy-, methyl ester; Methyl 6-methoxy-2-picolinate; C₈H₉NO₃ heterocycle; MFCD07779517
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Chinese Synonyms
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6-甲氧基-2-吡啶甲酸甲酯; 甲基6-甲氧基吡啶-2-羧酸酯; 6-甲氧基吡啶甲酸甲酯; 甲氧基吡啶甲酸甲酯
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Molecular Formula
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C₈H₉NO₃
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Molecular Weight
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167.16 g/mol
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Purity
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≥ 98% (GC/HPLC)
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Product Category
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Pharmaceutical Intermediates / Pyridine Derivatives / Methoxypicolinates
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Appearance
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White to Off-white Crystalline Powder or Low-Melting Solid
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Melting Point
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33-39°C (literature)
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Boiling Point
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~260-265°C at 760 mmHg (estimated)
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Density
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~1.16 g/cm³ (estimated)
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Storage Conditions
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Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Protect from strong oxidizing agents and bases. Store sealed at 2-8°C for extended stability.
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Shelf Life
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24 months under recommended storage conditions
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Packaging
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100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
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Applications
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Pharmaceutical intermediates, organic synthesis, API manufacturing, kinase inhibitor synthesis, heterocyclic chemistry, ester hydrolysis to acid, nucleophilic aromatic substitution, agrochemical intermediates, fine chemical production
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Reactivity
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Suitable for ester hydrolysis to acid, amide formation, Suzuki coupling, Buchwald-Hartwig amination, nucleophilic aromatic substitution, and methoxy-directed ortho-functionalization
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