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Pyrimidine
Pyrimidine (CAS 289-95-2), also known as 1,3-Diazine or m-Diazine, is a high-purity heterocyclic aromatic nitrogenous base widely used in pharmaceutical synthesis, organic chemistry research, nucleic acid chemistry, and fine chemical manufacturing. This compound features a six-membered aromatic ring containing two nitrogen atoms at the 1,3-positions (meta-position), making it a fundamental building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in heterocyclic synthesis, nucleophilic substitution, and functional group transformations, it exhibits excellent reactivity in electrophilic aromatic substitution, cross-coupling reactions, and derivatization pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, nucleoside synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing pyrimidine scaffolds, antiviral drug intermediates, anticancer agent precursors, and specialty chemical precursors. As a reliable heterocyclic intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.
Property
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Product Name
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Pyrimidine
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CAS Number
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289-95-2
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Chinese Name
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嘧啶
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Synonyms
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1,3-Diazine; m-Diazine; Metadiazine; Pyrimidine free base; 1,3-Diazabenzene; Pyrimidine base; C₄H₄N₂ heterocycle
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Chinese Synonyms
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间二氮杂苯; 1,3-二氮杂苯; 嘧啶游离碱; 嘧啶碱基
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Molecular Formula
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C₄H₄N₂
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Molecular Weight
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80.09 g/mol
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Purity
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≥ 98% (GC/NMR)
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Product Category
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Pharmaceutical Intermediates / Heterocyclic Compounds / Nitrogenous Bases
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Appearance
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Colorless to Light Yellow Liquid or Crystalline Solid
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Melting Point
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20-22°C (literature)
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Boiling Point
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123-124°C (literature)
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Density
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~1.016 g/cm³ (estimated)
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Refractive Index
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n₂₀/D ~1.501-1.504
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Flash Point
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31°C
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Storage Conditions
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Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed. Store under inert atmosphere (nitrogen or argon). Refrigerate at 2-10°C.
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Shelf Life
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24 months under recommended storage conditions
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Packaging
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100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
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Applications
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Pharmaceutical intermediates, organic synthesis, API manufacturing, nucleoside synthesis, antiviral drug development, anticancer agent synthesis, heterocyclic chemistry, agrochemical intermediates, fine chemical production
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Reactivity
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Suitable for electrophilic aromatic substitution, nucleophilic substitution, cross-coupling reactions, alkylation, acylation, and nitrogen-directed ortho-functionalization
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