tert-Butyl 3-bromopicolinate

tert-Butyl 3-bromopicolinate (CAS 1260807-49-5), also known as tert-Butyl 3-bromopyridine-2-carboxylate or 2-Pyridinecarboxylic acid, 3-bromo-, 1,1-dimethylethyl ester, is a high-purity brominated pyridine ester intermediate widely used in pharmaceutical synthesis, organic chemistry research, agrochemical development, and fine chemical manufacturing. This compound features a bromine substituent at the 3-position and a tert-butyl ester group at the 2-position of the pyridine ring, making it a versatile building block for the development of complex organic molecules and active pharmaceutical ingredients (APIs). As a key intermediate in cross-coupling reactions, nucleophilic aromatic substitution, and ester deprotection, it exhibits excellent reactivity in Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, and selective bromine displacement pathways. Our product is manufactured under strict quality control standards, ensuring a purity of ≥98%, making it ideal for pharmaceutical manufacturing, medicinal chemistry research, kinase inhibitor synthesis, and scale-up production. This compound is particularly valuable in the synthesis of pharmaceuticals containing bromopyridine scaffolds, heterocyclic kinase inhibitor intermediates, agrochemical precursors, and specialty chemical precursors. As a reliable pyridine derivative intermediate from our product line, it serves as an important precursor for constructing functionalized nitrogenous heterocyclic systems in drug discovery and fine chemical development programs.

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Product Name	tert-Butyl 3-bromopicolinate
CAS Number	1260807-49-5
Chinese Name	3-溴吡啶-2-羧酸叔丁酯
Synonyms	tert-Butyl 3-bromopyridine-2-carboxylate; 2-Pyridinecarboxylic acid, 3-bromo-, 1,1-dimethylethyl ester; 3-Bromo-2-picolinic acid tert-butyl ester; C₁₀H₁₂BrNO₂ heterocycle; MFCD09264589
Chinese Synonyms	3-溴-2-吡啶甲酸叔丁酯; 叔丁基3-溴吡啶-2-羧酸酯; 3-溴吡啶甲酸叔丁酯; 溴代吡啶甲酸叔丁酯
Molecular Formula	C₁₀H₁₂BrNO₂
Molecular Weight	258.11 g/mol
Purity	≥ 98% (GC/HPLC)
Product Category	Pharmaceutical Intermediates / Pyridine Derivatives / Bromopicolinates
Appearance	White to Off-white Crystalline Powder or Low-Melting Solid
Storage Conditions	Store in a cool, dry, well-ventilated area away from light and moisture. Keep container tightly closed under inert atmosphere (nitrogen or argon). Protect from strong oxidizing agents and bases. Store at 2-8°C for extended stability.
Shelf Life	24 months under recommended storage conditions
Packaging	100g/bottle, 500g/bottle, 1kg/bottle, 5kg/drum, or customized according to customer requirements
Applications	Pharmaceutical intermediates, organic synthesis, API manufacturing, kinase inhibitor synthesis, heterocyclic chemistry, Suzuki coupling, Buchwald-Hartwig amination, ester deprotection to acid, agrochemical intermediates, fine chemical production
Reactivity	Suitable for Suzuki coupling, Buchwald-Hartwig amination, Sonogashira coupling, nucleophilic aromatic substitution, ester hydrolysis/deprotection, and bromine-directed ortho-functionalization