7-Methoxycoumarin-4-acetic acid

7-Methoxycoumarin-4-acetic acid (CAS 62935-72-2) is a strategically functionalized coumarin derivative engineered for fluorescent probe development, bioconjugation chemistry, and pharmaceutical scaffold design. This molecule integrates a 7-methoxycoumarin core—a privileged fluorophore scaffold known for blue fluorescence and high quantum yield—with an acetic acid side chain at the C4 position, creating a versatile handle for amide coupling, esterification, or bioconjugation to biomolecules. The 7-methoxy substituent enhances electron-donating capacity and fluorescence intensity through intramolecular charge transfer (ICT), while the C4-acetic acid moiety provides orthogonal reactivity for linker attachment without perturbing the coumarin chromophore. This intermediate is particularly valuable for constructing fluorescent labels for protein/DNA tagging, FRET pair donors, and CNS-penetrant drug scaffolds where the coumarin-acetate motif balances photophysical properties with synthetic flexibility. Manufactured under controlled conditions, it supports research programs requiring modular access to positionally defined coumarin architectures with tunable emission profiles.