Ethyl 3-bromo-1h-pyrazole-5-carboxylate

Ethyl 3-bromo-1H-pyrazole-5-carboxylate (CAS 1886994-07-5) is a high-purity, regiochemically defined heterocyclic building block widely used in pharmaceutical intermediates and medicinal chemistry . This strategically brominated pyrazole ester features two orthogonal reactive handles: a C3-bromine atom for diverse palladium-catalyzed cross-coupling reactions, and a C5-ethyl ester for hydrolysis or amide coupling . The unique 3,5-substitution pattern creates a distinct electronic distribution across the pyrazole ring, making this regioisomeric scaffold particularly valuable for constructing kinase inhibitors, ERK inhibitors for regulating cell proliferation and apoptosis, and agrochemical active ingredients where precise positional control dictates binding orientation in target pockets . Manufactured under controlled conditions with purity ≥95-98% , this intermediate supports drug discovery programs requiring modular diversification of nitrogen-rich heterocyclic architectures with precise regiochemical control.